Abstract | BACKGROUND: As large numbers of children are accessing antiretroviral therapy (ART) in India, we evaluated the dietary intake, growth pattern and risk of metabolic complications like dyslipidemia and insulin resistance among ART-naïve HIV-infected children (CLHIV). METHODS: CLHIV 2-12 years of age, at the time of initiating ART in Chennai and Bangalore, were assessed for their dietary intake, anthropometry, blood CD4 cell count, HIV-1 viral load, fasting serum lipids, glucose and insulin. Homeostatic model assessment- insulin resistance was derived. RESULTS: CONCLUSIONS: In the background of high food insecurity and malnutrition, cardiometabolic abnormalities were seen in 20%-35% of ART-naïve CLHIV in India emphasizing close monitoring of these children for long-term cardiovascular morbidities after initiation of ART.
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Authors | C Padmapriyadarsini, Anita Shet, R Srinivasan, Geetha Ramachandran, G N Sanjeeva, Poornaganga Devi, K Ramesh, Perumal K Bhavani, Devaraj Reddy, E Suresh, C Chandrasekhar, Christine Wanke, Soumya Swaminathan |
Journal | The Pediatric infectious disease journal
(Pediatr Infect Dis J)
Vol. 37
Issue 3
Pg. 253-257
(03 2018)
ISSN: 1532-0987 [Electronic] United States |
PMID | 29189659
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Antiretroviral Therapy, Highly Active
(adverse effects, methods)
- Biomarkers
- Child
- Child, Preschool
- Female
- HIV Infections
(blood, drug therapy, epidemiology, virology)
- Humans
- India
(epidemiology)
- Insulin Resistance
- Lipids
(blood)
- Male
- Odds Ratio
- Population Surveillance
- Prevalence
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