Abstract | OBJECTIVE: METHODS: RESULTS: Serum FGF21 increased 3-fold at 120 min after fructose ingestion and returned to basal levels at 300 min. Neither basal FGF21 nor the fructose-FGF21 response correlated with liver fat content or liver histopathology, but increased levels were associated with elevated endogenous glucose production, increased lipolysis, and peripheral/muscle insulin resistance. At 1-year follow-up, subjects had lost 28 ± 6% of body weight and improved in all metabolic outcomes, but fructose-stimulated FGF21 dynamics did not markedly differ from the pre-surgical state. The association between increased basal and stimulated FGF21 levels with poor metabolic health was no longer present after weight loss. CONCLUSIONS:
Fructose ingestion in obese humans stimulates FGF21 secretion, and this response is related to systemic metabolism. Further studies are needed to establish if FGF21 signaling is (patho)physiologically involved in fructose metabolism and metabolic health.
|
Authors | Kasper W Ter Horst, Pim W Gilijamse, Ahmet Demirkiran, Bart A van Wagensveld, Mariette T Ackermans, Joanne Verheij, Johannes A Romijn, Max Nieuwdorp, Eleftheria Maratos-Flier, Mark A Herman, Mireille J Serlie |
Journal | Molecular metabolism
(Mol Metab)
Vol. 6
Issue 11
Pg. 1493-1502
(11 2017)
ISSN: 2212-8778 [Electronic] Germany |
PMID | 29107295
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2017 The Authors. Published by Elsevier GmbH.. All rights reserved. |
Chemical References |
- Blood Glucose
- Insulin
- fibroblast growth factor 21
- Fructose
- Fibroblast Growth Factors
- Glucose
|
Topics |
- Adult
- Bariatric Surgery
(methods)
- Blood Glucose
(metabolism)
- Energy Metabolism
(drug effects)
- Fatty Liver
(blood)
- Female
- Fibroblast Growth Factors
(blood)
- Fructose
(administration & dosage)
- Fructose Intolerance
(metabolism)
- Gastric Bypass
(methods)
- Glucose
(metabolism)
- Humans
- Insulin
(blood)
- Insulin Resistance
- Liver
(metabolism)
- Male
- Middle Aged
- Obesity
(blood)
- Obesity, Morbid
(blood)
- Weight Loss
|