Gastric Bypass (Roux-en-Y Gastric Bypass)

Surgical procedure in which the STOMACH is transected high on the body. The resulting small proximal gastric pouch is joined to any parts of the SMALL INTESTINE by an end-to-side SURGICAL ANASTOMOSIS, depending on the amounts of intestinal surface being bypasses. This procedure is used frequently in the treatment of MORBID OBESITY by limiting the size of functional STOMACH, food intake, and food absorption.

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Networked: 4481 relevant articles (420 outcomes, 454 trials/studies)

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Therapy Context: Research Results

Experts

1.	Nguyen, Ninh T: 45 articles (05/2015 - 05/2002)
2.	Szomstein, Samuel: 42 articles (11/2015 - 12/2003)
3.	Lee, Wei-Jei: 31 articles (10/2015 - 05/2005)
4.	le Roux, Carel W: 29 articles (10/2015 - 11/2007)
5.	Ikramuddin, Sayeed: 27 articles (12/2015 - 02/2003)
6.	Gagner, Michel: 27 articles (11/2015 - 02/2002)
7.	Sarr, Michael G: 27 articles (07/2015 - 02/2003)
8.	Rosenthal, Raul J: 26 articles (11/2015 - 09/2004)
9.	Olbers, Torsten: 25 articles (10/2015 - 06/2003)
10.	Csendes, Attila: 23 articles (06/2014 - 03/2004)

Related Diseases

1.	Weight Loss (Weight Reduction) 06/01/2015 - "Bariatric surgery is arguably the most effective therapy for weight loss, and Rouen-Y gastric bypass (RYGB) is considered the "gold-standard" procedure. " 01/01/2014 - "Long limb gastric bypass in obese patients results in significant and sustained weight loss which predicts a high remission rate of MS and allows the discontinuation of drug therapy for several metabolic disturbances in most patients." 09/01/2013 - "We conclude that gastric bypass surgery yields significant weight loss for most patients in Veterans Affairs Medical Centers, but is particularly effective for female and Caucasian patients." 03/01/2013 - "Among all types of intervention, the most frequently used is Roux-en-Y gastric bypass, an intervention both restrictive and malabsorptive, which leads to best results in weight loss. " 12/01/2012 - "Roux-en-Y Gastric Bypass is the gold standard procedure for weight loss surgery and is the most commonly performed bariatric operation in the United States. "
2.	Morbid Obesity 05/01/2011 - "Roux-en-Y gastric bypass surgery (RYGB) is currently the most effective treatment for morbid obesity, and clinical studies suggest that RYGB patients change food preferences and the desire to eat. " 09/01/2015 - "Roux-en-Y gastric bypass (RYGB) is the most effective treatment for morbid obesity and resolution of diabetes. " 05/01/2014 - "The most frequently used and effective treatment for morbid obesity is Roux-en-Y gastric bypass surgery (RYGB), which results in rapid remission of type 2 diabetes in most cases. " 03/01/2014 - "Laparoscopic Roux-en-Y gastric bypass (LRYGB) is the most effective treatment for morbid obesity. " 01/01/2014 - "Bariatric surgery is indicated as the most effective treatment for morbid obesity; the Roux-en-Y gastric bypass (RYGB) is considered the procedure of choice. "
3.	Obesity 01/01/2015 - "Roux-en-Y gastric bypass (RYGB) is highly effective in reversing obesity and associated diabetes. " 07/15/2014 - "Bariatric surgery is currently the most effective treatment for severe obesity, and Roux-en-Y gastric bypass (RYGB) is the most common approach in the United States and worldwide. " 12/01/2013 - "Bariatric surgery is effective in the management of type 2 diabetes (T2D) and obesity; however, it is not clear whether Roux-en-Y gastric bypass (GBP) or sleeve gastrectomy (SG) is the most effective procedure. " 12/17/2004 - "This study confirms that gastric bypass is a very effective treatment for severe obesity and can be performed with a high level of safety. " 01/01/2010 - "Non-transectional open gastric bypass for patients with BMI of 70 and higher is safe and effective as a one-stage operation for severe obesity."
4.	Type 2 Diabetes Mellitus (MODY) 07/01/2011 - "Most morbidly obese patients who undergo gastric bypass experience rapid remission of type 2 diabetes mellitus (T2DM) but the response in non-morbidly obese patients is not clear. " 06/01/2009 - "For over 2 decades, bariatric surgeons have recognized that gastric bypass surgery causes a remarkable, durable improvement in type 2 diabetes mellitus. " 01/01/2009 - "Although the long-term efficacy of Roux-en-Y gastric bypass is not known, these findings suggest that Roux-en-Y gastric bypass is an effective option for the treatment of extremely obese adolescents with type 2 diabetes mellitus." 11/01/2005 - "Is Roux-en-Y gastric bypass surgery the most effective treatment for type 2 diabetes mellitus in morbidly obese patients?" 10/01/2015 - "Our aim is to clarify the features of complete type 2 diabetes mellitus (T2DM) remission in patients who undergo Roux-en Y gastric bypass surgery, to better determine factors affecting the outcome of T2DM surgery. "
5.	Insulin Resistance 12/01/2013 - "Previous studies showed that early after Roux-en-Y gastric bypass (RYGB), there is a remarkable improvement in type 2 diabetes, which is characterized by insulin resistance. " 04/01/2005 - "There was marked loss of/improvement in insulin resistance within 6 days of gastric bypass by both IVGTT and HOMA methods in all groups, which was maintained over the 12-month period. " 01/01/2010 - "Biliopancreatic diversion and gastric bypass are associated with a rapid improvement in insulin resistance few days after surgery. " 01/01/2013 - "Sleeve gastrectomy and Roux-en-Y gastric bypass are equally effective in correcting insulin resistance." 01/01/2013 - "Although medium- to long-term improvement in insulin resistance and T2DM after Roux-en-Y gastric bypass (RYGB) is well documented, few studies have analyzed the acute effects after surgery. "

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3.	Carbon Monoxide
4.	Hormones
5.	Fibrin Tissue Adhesive (Fibrin Sealant)
6.	Leptin
7.	Non-alcoholic Fatty Liver Disease
8.	Glycosylated Hemoglobin A (Glycosylated Hemoglobin)
9.	Ghrelin
10.	Adiponectin

Related Therapies and Procedures

1.	Gastrectomy
2.	Bariatric Surgery
3.	Gastroplasty (Vertical-Banded Gastroplasty)
4.	Biliopancreatic Diversion
5.	Gastric Bypass (Roux-en-Y Gastric Bypass)