Existence of a Strong Correlation of Biomarkers and miRNA in Females with Metabolic Syndrome and Obesity in a Population of West Virginia.

Abstract

Objectives: Metabolic syndrome causes complications like cardiovascular disease and type 2 diabetes mellitus (T2DM). As metabolic syndrome develops, altered levels of cytokines and microRNAs (miRNA) are measurable in the circulation. We aimed to construct a panel detecting abnormal levels of cytokines and miRNAs in patients at risk for metabolic syndrome. Methods: Participants included 54 patients from a Family Medicine Clinic at Marshall University School of Medicine, in groups of: Control, Obese, and Metabolic Syndrome (MetS). Results: Serum levels of leptin, adiponectin, leptin: adiponectin ratio, IL-6, six miRNAs (320a, 197-3p, 23-3p, 221-3p, 27a-3p, and 130a-3p), were measured. Among the three groups, leptin, and leptin: adiponectin ratio, and IL-6 levels were highest in MetS, and levels in Obese were greater than Control (p>0.05). Adiponectin levels were lower in Obese compared to Control, but lowest in MetS (p<0.05). MiRNAs levels were lowest in MetS, and levels in Obese were lower than Control (p>0.05). Conclusion: Our results support the clinical application of biomarkers in diagnosing early stage MetS, which will enable attenuation of disease progression before onset of irreversible complications. Since West Virginians are high-risk for developing MetS, our biomarker panel could reduce the disease burden on our population.

• Authors: Perrine Goguet-Rubio, Rebecca L Klug, Dana L Sharma, Krithika Srikanthan, Nitin Puri, Vishal H Lakhani, Alexandra Nichols, Kathleen M O'Hanlon, Nader G Abraham, Joseph I Shapiro, Komal Sodhi
• Journal: International journal of medical sciences (Int J Med Sci) Vol. 14 Issue 6 Pg. 543-553 ( 2017) ISSN: 1449-1907 [Electronic] Australia
• PMID: 28638270 (Publication Type: Journal Article)

Chemical References

• ADIPOQ protein, human
• Adiponectin
• Biomarkers
• Interleukin-6
• Leptin
• MicroRNAs

Topics

• Adiponectin (blood)
• Adult
• Biomarkers (blood)
• Cardiovascular Diseases (blood, epidemiology, pathology)
• Diabetes Mellitus, Type 2 (blood, epidemiology, pathology)
• Female
• Humans
• Interleukin-6 (blood)
• Leptin (blood)
• Metabolic Syndrome (blood, epidemiology, pathology)
• MicroRNAs (blood)
• Obesity (blood, epidemiology, pathology)
• Risk Factors