Abstract | BACKGROUND/AIMS: Oxidative stress plays an important role in the pathogenesis and progression of diabetic complications and antagonists of renin-angiotensin system and amlodipine have been reported previously to reduce oxidative stress. In this study, we compared the changes in oxidative stress markers after valsartan and amlodipine treatment in type 2 diabetic patients with hypertension and compared the changes in metabolic parameters. METHODS: RESULTS: After 24 weeks of valsartan or amlodipine treatment, systolic and diastolic blood pressure decreased, with no significant difference between the groups. Both groups showed a decrease in serum nitrotyrosine (7.74 ± 7.30 nmol/L vs. 3.95 ± 4.07 nmol/L in the valsartan group and 8.37 ± 8.75 nmol/L vs. 2.68 ± 2.23 nmol/L in the amlodipine group) with no significant difference between the groups. Other parameters including glucose, lipid profile, albumin-to- creatinine ratio, and homeostasis model assessment of insulin resistance showed no significant differences before and after treatment in either group. CONCLUSIONS:
|
Authors | Hae Jin Kim, Seung Jin Han, Dae Jung Kim, Hak Chul Jang, Soo Lim, Sung Hee Choi, Yong Hyun Kim, Dong Hyun Shin, Se Hwa Kim, Tae Ho Kim, Yu Bae Ahn, Seung Hyun Ko, Nan Hee Kim, Ji A Seo, Ha Young Kim, Kwan Woo Lee |
Journal | The Korean journal of internal medicine
(Korean J Intern Med)
Vol. 32
Issue 3
Pg. 497-504
(May 2017)
ISSN: 2005-6648 [Electronic] Korea (South) |
PMID | 28490725
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
|
Chemical References |
- Antihypertensive Agents
- Amlodipine
- Valsartan
|
Topics |
- Amlodipine
(pharmacology, therapeutic use)
- Antihypertensive Agents
(pharmacology, therapeutic use)
- Diabetes Mellitus, Type 2
(complications)
- Female
- Humans
- Hypertension
(complications, drug therapy)
- Male
- Middle Aged
- Oxidative Stress
(drug effects)
- Valsartan
(pharmacology, therapeutic use)
|