HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Amlodipine (Norvasc)

A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.

Also Known As:

Norvasc; Istin; Almirall Brand of Amlodipine Besilate; Amlodipine Besylate; Amlodipine Maleate; Amlodipine Maleate (1:1); Amlodipine, (+-)-Isomer; Amlodipine, (+-)-Isomer, Maleate (1:1); Amlodipine, (R)-Isomer; Amlodipine, (S)-Isomer, Maleate (1:1); Amlodis; Amlor; Astudal; Eczacibasi Brand of Amlodipine besilate; Mack Brand of Amlodipine Besilate; Pfizer Brand of Amlodipine Besilate; 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester

Networked: 2023 relevant articles (304 outcomes, 709 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Pyridines: 41
    - Dihydropyridines: 177
      - Amlodipine: 2023
        valsartan drug combination amlodipine: 51
        atorvastatin drug combination amlodipine: 33
        telmisartan amlodipine combination: 14
        perindopril drug combination amlodipine: 6
        amlodipine nicotinate: 3
        Exforge HCT: 1
        Tribenzor: 1
        CJX1 cpd
        CJX2 cpd

Experts

1.	Davis, Barry R: 28 articles (01/2016 - 04/2005)
2.	Oparil, Suzanne: 21 articles (01/2016 - 09/2006)
3.	ALLHAT Collaborative Research Group: 19 articles (01/2016 - 02/2001)
4.	Ford, Charles E: 18 articles (01/2016 - 04/2005)
5.	Derosa, Giuseppe: 17 articles (01/2015 - 09/2004)
6.	Bakris, George L: 16 articles (04/2015 - 05/2003)
7.	Chrysant, Steven G: 16 articles (01/2014 - 06/2006)
8.	Wright, Jackson T: 16 articles (05/2013 - 09/2004)
9.	Mugellini, Amedeo: 14 articles (01/2015 - 04/2004)
10.	Weber, Michael A: 14 articles (04/2014 - 05/2003)

Related Diseases

1.	Hypertension (High Blood Pressure) 01/01/2011 - "In this open-label, single-arm switch study reflecting clinical practice, patients with moderate hypertension not controlled by the free combination of CAN 32 + HCT 25 achieved a clinically and statistically significant reduction of blood pressure from the single pill combination of ALIS 300/HCT 25, and the optional addition of amlodipine." 09/01/2007 - "The clinical efficacy of amlodipine in improving hemodynamic variables and reducing cardiovascular events in isolated systolic hypertension could be explained by its beneficial effect on vascular calcification. " 12/01/2000 - "Once-daily amlodipine was effective in the treatment of mild to moderate hypertension in this patient population and demonstrated a low frequency of adverse events, a high degree of tolerability, and improved well-being. " 11/01/1996 - "Amlodipine has a beneficial effect on LVH and also is an effective and safe drug to treat mild to moderate hypertension." 05/01/2013 - "This study showed that an OA FDC is more effective than DA in reducing SBP for mild to moderate hypertension after the failure of amlodipine monotherapy."
2.	Stroke (Strokes) 11/01/2008 - "The trial was terminated early due to significant benefits on mortality and stroke associated with the amlodipine-based regimen. " 06/10/2010 - "In this study, we investigated whether amlodipine protects against the reduction in bone density in stroke-prone spontaneously hypertensive rats (SHR-sp). " 07/01/2007 - "The metaregression analysis correlating odds ratios with blood pressure differences showed a negative relationship (regression coefficients: -3% to -8%), which reached statistical significance (regression coefficient: -6%; P=0.01) for stroke in trials involving an amlodipine group. " 06/01/2006 - "The doses chosen for this trial were biased in favour of amlodipine, in terms of expected effects on blood pressure, cardiovascular mortality and strokes. " 01/01/2006 - "The aim of the present study was to examine whether treatment with amlodipine reduced oxidative stress in the brains of stroke-prone spontaneously hypertensive rats (SHRSP). "
3.	Angina Pectoris 01/01/1992 - "Once-daily administration of amlodipine is a highly effective treatment for patients with angina pectoris. " 10/01/1992 - "Amlodipine in patients with stable angina pectoris significantly improved the exercise tolerance and the function of the left ventricle in a dose-dependent way. " 11/01/1989 - "From the evidence available, it is concluded that once-daily treatment with amlodipine in the dose range of 5 to 10 mg is effective in improving exercise capacity and reducing anginal attack rate in patients with chronic stable angina pectoris and also those with vasospastic angina." 01/01/1991 - "The study showed clearly that addition of amlodipine to beta-blocker therapy in patients with stable angina pectoris was well tolerated and gave improved antianginal efficacy." 01/01/1991 - "The anti-anginal efficacy of amlodipine was investigated in patients with angina pectoris by means of atrial pacing during cardiac catheterization. "
4.	Heart Failure 11/01/1998 - "To date, amlodipine has been associated with the most promising results, with evidence of a mortality benefit in nonischemic heart failure. " 03/01/2000 - "The addition of 10 mg of amlodipine per day to standard therapy in patients with heart failure is associated with no significant improvement in exercise time compared with placebo therapy over a 12-week period, and there was no increased incidence of adverse events. " 12/31/1997 - "In our recent study, amlodipine improved histopathological lesions in the heart and survival rates in a murine model of nonischemic heart failure induced by encephalomyocarditis virus. " 01/01/1998 - "Amlodipine, in addition to standard therapy (including in all cases an ACE inhibitor), reduced symptoms and improved exercise capacity and ventricular function in patients with mild to moderate heart failure due to myocardial ischaemia. " 10/01/2013 - "Consistent with this finding, CTDN was more effective than amlodipine in reducing congestive heart failure (CHF) in the Anti-hypertensive and Lipid-lowering Treatment to Prevent Heart Attach Trial (ALLHAT). "
5.	Ischemia 12/01/2008 - "Conservative treatment with amlodipine is effective in reducing tissue damage induced by ischemia, I/R, or both in ovaries." 02/01/2015 - "The aim of this study was to determine whether amlodipine and/or perindoprilate injected intravenously (iv) prior to ischemia exerted protective effects on mitochondria structural and functional alterations induced by ischemia and aggravated by reperfusion. " 04/01/2011 - "The aim of this study was to determine the potential, protective effects of amlodipine in an experimental, ischemia-reperfusion (I/R) model in the rabbit small intestine. " 01/01/1994 - "Amlodipine and the total ischemic burden: circadian anti-ischemia program in Europe (CAPE) trial-methodology, safety and toleration. " 02/01/2015 - "Heart rate, the duration of monophasic action potentials (dMAP), peak of the time derivative of left ventricular pressure (LV dP/dt max), mitochondria structural and functional parameters in the left ventricle ischemic area were measured after 45-min ischemia and 1-min reperfusion in domestic pigs either untreated or pretreated with amlodipine, perindoprilate or amlodipine + perindoprilate. "

Related Drugs and Biologics

1.	Hydrochlorothiazide (Esidrix)
2.	valsartan (Vals)
3.	Calcium Channels (Calcium Channel)
4.	Losartan (Cozaar)
5.	Nifedipine (Adalat)
6.	Calcium
7.	olmesartan medoxomil (Votum)
8.	1,4-dihydropyridine (dihydropyridine)
9.	benazepril (Briem)
10.	aliskiren

Related Therapies and Procedures

1.	Chronotherapy
2.	Oral Administration
3.	Renal Dialysis (Hemodialysis)
4.	Angioplasty (Angioplasty, Transluminal)
5.	Transplants (Transplant)