Esmolol reduces apoptosis and inflammation in early sepsis rats with abdominal infection.

Abstract

BACKGROUND:

Esmolol is a highly selective beta 1 receptor blocker with various effects such as slowing heart rate, lowering blood pressure and reducing myocardial oxygen consumption. However, few studies have reported the use of beta blockers in sepsis with multiple organ dysfunctions. This study aimed to investigate the effects of esmolol on reducing apoptosis and inflammation in early sepsis rats with abdominal infection.

METHODS:

Rats were randomly divided into sham operation group, sepsis group, antibiotic group, Esmolol + antibiotic group with low, median and high dose Esmolol (L group, M group and H group). Values between two or more groups were compared by independent t-tests.

RESULTS:

In the liver and kidney, we found inflammatory infiltration in sepsis group while pathological aspects reduced in L, M and H groups. Bcl-2 mRNA and protein levels increased while Bax mRNA and protein levels decreased in the liver and kidney of L, M and H groups. Serum IL-6, HMGB-1 and TNF-α levels decreased but IL-10 level increased in L, M and H groups, compared to sepsis group. Compared to sepsis and antibiotic groups, the levels of myocardial enzymes were lower in L, M and H groups.

CONCLUSION:

The administration of esmolol in early sepsis may reduce inflammation, inhibit apoptosis and protect key organs.

• Authors: Yang Lu, Yang Yang, Xin He, Shangwen Dong, Wanhua Wang, Donghao Wang, Peng Zhang
• Journal: The American journal of emergency medicine (Am J Emerg Med) Vol. 35 Issue 10 Pg. 1480-1484 (Oct 2017) ISSN: 1532-8171 [Electronic] United States
• PMID: 28457762 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier Inc. All rights reserved.

Chemical References

• Adrenergic beta-1 Receptor Antagonists
• Anti-Bacterial Agents
• HMGB1 Protein
• Inflammation Mediators
• Interleukin-6
• Propanolamines
• Proto-Oncogene Proteins c-bcl-2
• Tumor Necrosis Factor-alpha
• bcl-2-Associated X Protein
• esmolol

Topics

• Abdomen (surgery)
• Adrenergic beta-1 Receptor Antagonists (therapeutic use)
• Animals
• Anti-Bacterial Agents (therapeutic use)
• Apoptosis
• Disease Models, Animal
• HMGB1 Protein (metabolism)
• Inflammation Mediators (metabolism)
• Interleukin-6 (metabolism)
• Male
• Propanolamines (therapeutic use)
• Proto-Oncogene Proteins c-bcl-2 (metabolism)
• Rats
• Sepsis (drug therapy, metabolism, pathology)
• Surgical Wound Infection (complications, metabolism, pathology)
• Tumor Necrosis Factor-alpha (metabolism)
• bcl-2-Associated X Protein (metabolism)