Abstract | OBJECTIVE: METHODS: Study participants were aged 53 to 73 years and not using hormone therapy at baseline (1998-2001) when FSH was measured. Prevalence of T2D was assessed at baseline, along with fasting insulin and glucose levels. Incident T2D, and insulin and glucose levels were assessed 7 to 9 years later at follow-up examination. RESULTS: After adjustment for age, estradiol, body mass index, smoking, lipids levels, and other factors, women with higher FSH (>50 IU/L) had a lower prevalence of T2D (odds ratio 0.49, 95% confidence interval [CI] 0.28-0.86) than women with lower FSH. Each 1 unit increase in FSH level was associated with a significant 1.9% lower risk of T2D (95% CI 0.966-0.997, P = 0.02). Higher FSH was associated with marginally significant lower incidence of T2D at follow-up (hazard ratio 0.53, 95% CI 0.27-1.02). Baseline FSH levels were inversely correlated with fasting insulin and glucose levels at both baseline and follow-up visits (all P < 0.05). After adjustment, FSH was modestly associated with fasting insulin at baseline (P = 0.01) and at follow-up (P = 0.11). CONCLUSIONS: Higher postmenopausal FSH levels were associated with lower prevalent and incident T2D and fasting insulin levels. These findings warrant replication in larger prospective studies.
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Authors | Elizabeth R Bertone-Johnson, Jyrki K Virtanen, Leo Niskanen, Tarja Nurmi, Kimmo Ronkainen, Sari Voutilainen, Jaakko Mursu, Jussi Kauhanen, Tomi-Pekka Tuomainen |
Journal | Menopause (New York, N.Y.)
(Menopause)
Vol. 24
Issue 7
Pg. 796-802
(Jul 2017)
ISSN: 1530-0374 [Electronic] United States |
PMID | 28141661
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Insulin
- Follicle Stimulating Hormone
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Topics |
- Aged
- Blood Glucose
(analysis)
- Diabetes Mellitus, Type 2
(epidemiology, etiology)
- Female
- Finland
(epidemiology)
- Follicle Stimulating Hormone
(blood)
- Follow-Up Studies
- Humans
- Incidence
- Insulin
(blood)
- Insulin Resistance
- Middle Aged
- Odds Ratio
- Postmenopause
(blood)
- Prevalence
- Prospective Studies
- Risk Factors
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