Abstract | BACKGROUND: MATERIALS AND METHODS: RESULTS: Among 240 patients, 129 (53%) had a CAC score > 100 AUs. Multivariate analysis revealed that independent predictors of 1-SD higher CAC score were age, male gender, diabetes and use of statins. The association between CAC score and mortality remained significant after adjustment for age, gender, diabetes, CVD, use of statins, protein-energy wasting and inflammation. Repeated CAC imaging in 35 patients showed that statin therapy was associated with greater progression of CAC. In vitro synthesis of menaquinone-4 by hVSMCs was significantly impaired by statins. CONCLUSION:
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Authors | Zhimin Chen, Abdul Rashid Qureshi, Paolo Parini, Eva Hurt-Camejo, Jonaz Ripsweden, Torkel B Brismar, Peter Barany, Armand M Jaminon, Leon J Schurgers, Olof Heimbürger, Bengt Lindholm, Peter Stenvinkel |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Vol. 47
Issue 2
Pg. 137-148
(Feb 2017)
ISSN: 1365-2362 [Electronic] England |
PMID | 28036114
(Publication Type: Journal Article, Observational Study)
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Copyright | © 2016 Stichting European Society for Clinical Investigation Journal Foundation. |
Chemical References |
- Biomarkers
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Vitamin K
|
Topics |
- Adult
- Aged
- Biomarkers
(metabolism)
- Coronary Artery Disease
(chemically induced, mortality)
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(adverse effects)
- Kaplan-Meier Estimate
- Kidney Failure, Chronic
(complications, mortality)
- Male
- Middle Aged
- Muscle, Smooth, Vascular
(metabolism)
- Vascular Calcification
(chemically induced, mortality)
- Vitamin K
(metabolism)
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