Abstract | BACKGROUND: The obesogenic and diabetogenic effects of the environmental toxin bisphenol A during critical windows of development are well recognized. Liver and skeletal muscle play a central role in the control of glucose production, utilization, and storage. OBJECTIVES: STUDY DESIGN: RESULTS: CONCLUSION: Maternal bisphenol A had sex- and tissue-specific effects on insulin signaling components, which may contribute to increased risk of glucose intolerance in offspring. Glucose transporters were consistently altered at both ages as well as in both sexes and may contribute to glucose intolerance. These data suggest that maternal bisphenol A exposure should be limited during pregnancy and lactation.
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Authors | Kristina D Galyon, Farnoosh Farshidi, Guang Han, Michael G Ross, Mina Desai, Juanita K Jellyman |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 216
Issue 3
Pg. 290.e1-290.e9
(03 2017)
ISSN: 1097-6868 [Electronic] United States |
PMID | 27836638
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2016 Elsevier Inc. All rights reserved. |
Chemical References |
- Benzhydryl Compounds
- Insulin
- Phenols
- bisphenol A
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Topics |
- Animals
- Benzhydryl Compounds
(adverse effects)
- Female
- Insulin
(physiology)
- Liver
(drug effects, metabolism)
- Male
- Maternal Exposure
- Muscle, Skeletal
(drug effects, metabolism)
- Phenols
(adverse effects)
- Pregnancy
- Protein Biosynthesis
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Signal Transduction
(drug effects)
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