Previously we found that
hypertension potentiates the risk the cataractogenesis. In the present study, we investigated the protective effects of
magnesium taurate (MgT) on
hypertension and associated lenticular damages against
cadmium chloride (CdCl2)-induced hypertensive animals. Male Sprague-Dawley albino rats (150-180g) were assigned to five experimental groups (n=6). Among the five groups, normal group received 0.3%
carboxymethyl cellulose (10ml/kg/day, p.o.).
Hypertension control group received
CdCl2 (0.5mg/kg/day, i.p.). Tests and standard groups received MgT (3 and 6mg/kg/day, p.o.) and
amlodipine (3mg/kg/day, p.o.) concurrently with
CdCl2 respectively, for six consecutive weeks. Blood pressure, heart rate, and eyes were examined biweekly, and pathophysiological parameters in serum and eye
lenses were evaluated after six weeks of the experimental protocol. The chronic administration of MgT concurrently with
CdCl2 significantly restored the blood pressure, serum and lens
antioxidants (CAT, SOD, GPx, and GSH), MDA level, and
ions (Na+, K+, and Ca2+). Additionally, MgT treatment led to significant increase in the
lens proteins (total and soluble),
Ca2+ ATPase, and Na+K+
ATPase activity as compared to
hypertension control group. Ophthalmoscope observations indicated that MgT
treatments delayed the progression of
cataract against the hypertensive state. The study shows that MgT prevents the progression of cataractogenesis via restoration of blood pressure, lenticular oxidative damages, and lens
ATPase functions in the hypertensive state. The results suggest that MgT supplement may play a beneficial role to manage
hypertension and associated cataractogenesis.