Abstract | BACKGROUND: METHODS: RESULTS: Compared with levels in the reference group, the median concentrations of C4d, C3bBbP and sTCC in the OA, RA, PPA and knee injury groups were 2- to 34-fold increased (p < 0.001 to p = 0.044). For the knee injury group, the median concentrations of C4d, C3bBbP and sTCC were 5- to 12-fold increased (p < 0.001) at the day of injury; after 3-12 weeks, C3bBbP and sTCC concentrations were similar to reference levels; and C4d was still increased several years after injury. In the 0-12 weeks period after injury, the concentrations of C4d, C3bBbP and sTCC correlated positively with levels of interleukin (IL)-1β, IL-6 and tumour necrosis factor α (r s range 0.232-0.547); none of the measured complement factors correlated with proteolytic fragments of aggrecan or cartilage oligomeric matrix protein. Knees with osteochondral fracture, with or without disrupted cortical bone, had higher concentrations of C4d (p = 0.014, p = 0.004) and sTCC (p = 0.004, p < 0.001) compared with knees without fractures. CONCLUSIONS:
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Authors | André Struglics, Marcin Okroj, Per Swärd, Richard Frobell, Tore Saxne, L Stefan Lohmander, Anna M Blom |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 18
Issue 1
Pg. 223
(10 06 2016)
ISSN: 1478-6362 [Electronic] England |
PMID | 27716448
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Complement C4
- Complement Membrane Attack Complex
- Complement C3b
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Topics |
- Adult
- Aged
- Cohort Studies
- Complement Activation
(immunology)
- Complement C3b
(analysis)
- Complement C4
(analysis)
- Complement Membrane Attack Complex
(analysis)
- Cross-Sectional Studies
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Knee Injuries
(blood, immunology, pathology)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Osteoarthritis, Knee
(blood, immunology, pathology)
- Synovial Fluid
(immunology)
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