Objective: To evaluate the clinical effect and safety of
oxycodone hydrochloride in the
anesthesia for percutaneous
radiofrequency ablation (PRFA) in
hepatocellular carcinoma. Methods: Between March and December 2015, 60 cases of
hepatocellular carcinoma patients undergoing percutaneous
radiofrequency ablation surgery in Peking University Cancer Hospital were randomly divided into three groups:
oxycodone group (group Q),
fentanyl group (group F) and
dezocine group (group D), 20 cases in each group. Respectively intravenously injection
oxycodone 0.1 mg/kg,
fentanyl 0.001 mg/kg,
dezocine 0.1 mg/kg before surgery. After the surgeon completed
puncture administer
propofol to maintain
anesthesia. Recorded mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR), oxygen saturation (SpO2) changes in each group at entrance, beginning of
radiofrequency ablation (T1),
radiofrequency ablation began after 10 minutes (T2), the end of the surgical and awake. Observe the
analgesia effect,
respiratory depression,
nausea, vomit and other complications.
Postoperative pain scores were recorded.Using ANOVA, repeated measure variance analysis, SNK test, χ2 test and other tests to evaluate the
anesthetic effect indexes. Results: The observation completed in all patients. Patients of three groups had no significant differences in general information. No significant difference between MAP, HR and SpO2 at each time points among the three groups. At the T1 time point (group Q: (11.7±1.6)/min, group D: (12.1±1.7)/min, group F: (10.3±2.3)/min, F=5.068, P=0.009) and T2 time point (group Q: (11.9±1.3)/min, group D: (12.2±1.4)/min, group F: (10.7±1.3)/min, F=7.024, P=0.002), RR in group F were lower than in group Q and group D.
Pain visual analogue scores after waking (group Q: 0.2±0.7, group D: 0.3±0.7, group F: 1.7±1.5, F=12.981, P=0.000) and
postoperative pain score of 1 hour (group Q: 2.0±0.9, group D: 1.8±0.8, group
F: 4.3±0.9, F=42.362, P=0.000) in the group Q and group D were significantly lower than in group F. The body movements in group Q and group D were significantly less than in group F (3 cases, 3 cases, 9 cases, χ2=6.400, P=0.041 ). Intraoperative
respiratory depression in group Q and group D were lower than group F (3 cases, 2 cases, 9 cases, χ2=8.012, P=0.018). Conclusions:
Oxycodone hydrochloride can be used safely and effectively for
radiofrequency ablation. It has favorable hemodynamic stability, lower incidence of
respiratory depression, and advantage in terms of
postoperative pain.