Background Dietary habits are associated with
obesity which is a risk factor for
coronary heart disease. The objective is to estimate the change of
lipoprotein(a) and other
lipoprotein classes by calorie restriction with
obesity index and Framingham risk score. Methods Sixty females (56 ± 9 years) were recruited. Their caloric intakes were reduced during the six-month period, and the calorie from fat was not more than 30%.
Lipoprotein profiles were estimated at baseline and after the six-month period of calorie restriction.
Cholesterol levels in six
lipoprotein classes (HDL,
LDL, IDL, VLDL,
chylomicron and
lipoprotein(a)) were analysed by
anion-exchange liquid chromatography. The other tests were analysed by general methods. Additionally, Framingham risk score for predicting 10-year
coronary heart disease risk was calculated. Results Body mass index, waist circumference,
insulin resistance, Framingham risk score, total
cholesterol, LDL-
cholesterol and
IDL-cholesterol were significantly decreased by the calorie restriction, and the
protein and
cholesterol levels of
lipoprotein(a) were significantly increased. The change of body mass index was significantly correlated with those of TC,
VLDL-cholesterol and
chylomicron-
cholesterol, and that of waist circumference was significantly correlated with that of
chylomicron-
cholesterol. The change of Framingham risk score was significantly correlated with the change of IDL-C. Conclusion
Obesity indexes and Framingham risk score were reduced by the
dietary modification.
Lipoprotein profile was improved with the reduction of
obesity indexes, but
lipoprotein(a) was increased. The changes of
obesity indexes and Framingham risk score were related with those of
triglyceride-rich
lipoproteins, e.g. IDL, VLDL and CM.