Combination of selenium-enriched green tea polysaccharides and Huo-ji polysaccharides synergistically enhances antioxidant and immune activity in mice.

Abstract

BACKGROUND:

The aim of this study was to investigate the influence of a combination of selenium-enriched green tea polysaccharides (Se-GTP) and Huo-ji polysaccharides (HJP) on the immune function and antioxidant activity in mice.

RESULTS:

The results showed that the indices of spleen and thymus were markedly increased, and the activity of natural killer (NK) cell was promoted in mice treated with the combination of Se-GTP and HJP. The combined treatment of Se-GTP and HJP also reduced the content of tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in splenocytes. In addition, the activities of glutathione peroxidase (GPx) and superoxide dismutase (SOD) were remarkably enhanced, and malondialdehyde (MDA) levels were significantly reduced in mice treated with combination of Se-GTP and HJP. Furthermore, the combined treatment of Se-GTP and HJP increased nuclear factor erythroid 2-related factor (Nrf2) expression at mRNA and protein levels in splenocytes. The effects of the combination treatment of Se-GTP and HJP in mice were stronger than with Se-GTP or HJP treatment alone.

CONCLUSION:

Our study suggests that the combined administration of Se-GTP and HJP can synergistically improve immune function and decrease the oxidative stress by enhancing the mechanisms involved in the clearance of free radicals.

• Authors: Chengfu Yuan, Zhihong Li, Fan Peng, Fangxiang Xiao, Dongming Ren, Hui Xue, Tao Chen, Gohar Mushtaq, Mohammad Amjad Kamal
• Journal: Journal of the science of food and agriculture (J Sci Food Agric) Vol. 95 Issue 15 Pg. 3211-7 (Dec 2015) ISSN: 1097-0010 [Electronic] England
• PMID: 26130565 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 Society of Chemical Industry.

Chemical References

• Adjuvants, Immunologic
• Antioxidants
• Cytokines
• NF-E2-Related Factor 2
• Nfe2l2 protein, mouse
• Plant Extracts
• Polysaccharides
• Selenium Compounds
• Trace Elements
• Malondialdehyde
• Glutathione Peroxidase
• Superoxide Dismutase
• Selenium

Topics

• Adjuvants, Immunologic (pharmacology)
• Animals
• Antioxidants (metabolism, pharmacology)
• Camellia sinensis (chemistry)
• Cytokines (metabolism)
• Drug Synergism
• Glutathione Peroxidase (metabolism)
• Immunity (drug effects)
• Killer Cells, Natural (metabolism)
• Malondialdehyde (metabolism)
• Mice
• NF-E2-Related Factor 2 (metabolism)
• Oxidative Stress (drug effects)
• Plant Extracts (pharmacology)
• Polysaccharides (pharmacology)
• Pyracantha (chemistry)
• Selenium (pharmacology)
• Selenium Compounds (pharmacology)
• Spleen (drug effects, metabolism)
• Superoxide Dismutase (metabolism)
• Thymus Gland (drug effects, metabolism)
• Trace Elements (pharmacology)