Abstract | BACKGROUND & AIMS: Levels of circulating of sex hormones are associated with glucose metabolism and adiposity, but little is known about their association with ectopic fat. We aimed to characterize the association between circulating sex hormones and liver fat. METHODS: RESULTS: Women in the highest tertile of bioavailable testosterone were significantly more likely to have fatty liver than women in the lowest tertile (odds ratio, 1.77; 95% confidence interval, 1.07-2.92). We found an even greater difference for level of estradiol (odds ratio, 2.49; 95% confidence interval, 1.41-4.39) after adjusting for age, race/ethnicity, waist-to-hip ratio, hypertension, total and high-density lipoprotein cholesterol, smoking, insulin sensitivity, and hormone replacement therapy use. Men in the highest tertile of estradiol level were significantly more likely to have fatty liver than men in the lowest tertile (odds ratio, 2.10; 95% confidence level, 1.29-3.40). Men in the highest tertile of SHBG were less likely to have fatty liver than those in the lowest tertile (odds ratio, 0.46; 95% confidence interval, 0.27-0.77). Other associations between hormone levels and fatty liver were not statistically significant. CONCLUSIONS: On the basis of a cross-sectional study, postmenopausal women with high levels of bioavailable testosterone are at greater risk for fatty liver. In men, higher levels of SHBG are associated with reduced risk for fatty liver. Higher levels of estradiol are associated with fatty liver in both sexes. This pattern is consistent with the sex-specific associations of sex hormones with other cardiometabolic risk factors.
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Authors | Mariana Lazo, Irfan Zeb, Khurram Nasir, Russell P Tracy, Matthew J Budoff, Pamela Ouyang, Dhananjay Vaidya |
Journal | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
(Clin Gastroenterol Hepatol)
Vol. 13
Issue 9
Pg. 1686-93.e2
(Sep 2015)
ISSN: 1542-7714 [Electronic] United States |
PMID | 25592661
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Cross-Sectional Studies
- Ethnicity
- Fatty Liver
(epidemiology, pathology)
- Female
- Gonadal Steroid Hormones
(blood)
- Humans
- Liver
(diagnostic imaging, pathology)
- Male
- Middle Aged
- Risk Assessment
- Tomography, X-Ray Computed
- United States
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