Abstract | CONTEXT: OBJECTIVE: DESIGN AND SETTING: An open, randomized, two-period, 12-week crossover multicentre trial in Norway and Sweden. PATIENTS: Ten Norwegian patients were admitted for 24-h sampling of hormone profiles. Fifteen Swedish patients underwent euglycaemic-hyperinsulinaemic clamp. INTERVENTION: MAIN OUTCOME MEASURE: RESULTS: Continuous subcutaneous hydrocortisone infusion provided a more physiological circadian cortisol curve including a late-night cortisol surge. ACTH levels showed a near normal circadian variation for CSHI. CSHI prevented a continuous decrease in glucose during the night. No difference in insulin sensitivity was observed between the two treatment arms. CONCLUSION: Continuous subcutaneous hydrocortisone infusion replacement re-established a circadian cortisol rhythm and normalized the ACTH levels. Patients with CSHI replacement had a more stable night-time glucose level compared with OHC without compromising insulin sensitivity. Thus, restoring night-time cortisol levels might be advantageous for patients with AD.
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Authors | Sigridur Björnsdottir, Marianne Øksnes, Magnus Isaksson, Paal Methlie, Roy M Nilsen, Steinar Hustad, Olle Kämpe, Anna-Lena Hulting, Eystein S Husebye, Kristian Løvås, Thomas Nyström, Sophie Bensing |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 83
Issue 1
Pg. 28-35
(Jul 2015)
ISSN: 1365-2265 [Electronic] England |
PMID | 25400085
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 John Wiley & Sons Ltd. |
Chemical References |
- Glucocorticoids
- Adrenocorticotropic Hormone
- Hydrocortisone
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Topics |
- Addison Disease
(drug therapy)
- Adrenocorticotropic Hormone
(blood)
- Adult
- Aged
- Circadian Rhythm
- Cross-Over Studies
- Female
- Glucocorticoids
(administration & dosage)
- Glucose Clamp Technique
- Hormone Replacement Therapy
(methods)
- Humans
- Hydrocortisone
(administration & dosage, blood)
- Infusions, Subcutaneous
- Insulin Resistance
- Male
- Middle Aged
- Norway
- Sweden
- Young Adult
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