Glucocorticoids

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

Networked: 7695 relevant articles (478 outcomes, 651 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Seckl, Jonathan R: 29 articles (12/2015 - 01/2003)
2.	Walker, Brian R: 22 articles (12/2015 - 12/2002)
3.	Cidlowski, John A: 22 articles (08/2015 - 06/2004)
4.	Bijlsma, Johannes W J: 22 articles (07/2015 - 01/2002)
5.	Buttgereit, Frank: 18 articles (02/2016 - 11/2004)
6.	Chrousos, George P: 18 articles (08/2015 - 03/2002)
7.	Saag, Kenneth G: 17 articles (08/2015 - 06/2002)
8.	Reichardt, Holger M: 17 articles (03/2015 - 06/2002)
9.	Adcock, Ian M: 17 articles (01/2014 - 04/2002)
10.	Stewart, Paul M: 17 articles (04/2013 - 03/2002)

Related Diseases

1.	Asthma (Bronchial Asthma) 01/01/2014 - "Glucocorticoids are the most effective anti-inflammatory treatment for allergic diseases, and inhaled glucocorticoids have now become the first-line treatment for asthma. " 01/01/2013 - "Although glucocorticoids (GC) are very effective for the treatment of most patients with asthma, an important subgroup of patients fails to show clinical improvement. " 01/01/2013 - "Glucocorticoids are widely regarded as the most effective treatment for asthma. " 09/01/2011 - "By repressing inflammatory gene expression, glucocorticoids are the most effective treatment for chronic inflammatory diseases such as asthma. " 12/01/2006 - "Glucocorticoids (GCS) are still the most effective treatment for asthma. "
2.	Inflammation 01/01/2013 - "Although glucocorticoids can be highly effective in treating inflammation, their systemic application is limited due to the high incidence of serious adverse effects, mainly in long-term treatment. " 05/01/2009 - "Glucocorticoids were most effective in controlling inflammation. " 08/01/2005 - "Glucocorticoids are very effective in controlling the inflammation seen in asthmatic airways. " 01/01/2001 - "Glucocorticoids in low doses have proven to be very effective in suppressing the inflammation associated with RA. " 10/01/1997 - "Therefore the use of topically active glucocorticoids with low systemic bioactivity for the treatment of allergic inflammation may be particularly effective in modulating the cytokine activity that is an important component of the allergic response."
3.	Rheumatoid Arthritis 05/01/2007 - "Clinical studies have also had major developments, most strikingly with the publication of two randomized prospective studies on the efficacy of glucocorticoids in preventing erosions in rheumatoid arthritis. " 01/01/2015 - "Glucocorticoids are one of the most effective treatments for rheumatoid arthritis, with well-established efficacy in controlling the disease symptoms and structural progression. " 06/01/2010 - "Glucocorticoids (GCs) provide one of the most effective treatments for rheumatoid arthritis (RA); however, their long-term use is marred by undesired side effects. " 06/01/2002 - "More than 50 years after their discovery, glucocorticoids continue to be a mainstay of treatment for many patients with rheumatoid arthritis (RA). " 10/01/2001 - "Resolved: Low-dose glucocorticoids are neither safe nor effective for the long-term treatment of rheumatoid arthritis."
4.	Pain (Aches) 02/15/2006 - "A single IV bolus of glucocorticoids provided significant improvement in sciatic leg pain (P = 0.04) within the first 3 days. " 01/01/2013 - "The study aims are therefore: to evaluate the efficacy of intra-articular glucocorticoids for knee or hip OA in specific subgroups of patients with severe pain and (mild) inflammatory signs, over both short-term and long-term follow-up, using IPD from existing studies; to reach consensus on the rules for cooperation in a consortium; and to develop and explore the methodological issues of meta-analysis with individual OA patient data. " 12/01/2005 - "[Efficacy of local treatment with glucocorticoids in regional pain syndromes appendix. " 12/01/2004 - "The efficacy of this therapy has not been conclusively proved; however, when weighed against the risks, cost, and outcomes of spinal surgery, epidural glucocorticoids are a reasonable alternative in selected patients whose back and leg pain is functionally limiting. " 10/19/2011 - "Although systemic glucocorticoids are frequently used for the treatment of radicular pain due to disc herniation, there are only few studies available. "
5.	Osteoporosis 01/01/2014 - "The efficacy of glucocorticoids (GCs) in treating a wide range of autoimmune and inflammatory conditions is blemished by severe side effects, including osteoporosis. " 04/01/2012 - "Quality of GIOP preventive care has improved but remains suboptimal with only one quarter of those starting long-term glucocorticoids receiving BMD testing or osteoporosis treatment. " 01/01/2014 - "Glucocorticoids predict 10-year fragility fracture risk in a population-based ambulatory cohort of men and women: Canadian Multicentre Osteoporosis Study (CaMos)." 11/01/2011 - "Eligible studies had to include patients at risk (women ≥ 65 years, men ≥ 70 years, and men/women ≥ 50 years with at least one major risk factor for osteoporosis) or at high risk (men/women using oral glucocorticoids or with previous fragility fractures) for osteoporosis and fractures. " 12/01/2010 - "Long-term administration of glucocorticoids may lead to bone loss and osteoporosis as reported in previous experimental and clinical studies. "

Related Drugs and Biologics

1.	Cyclophosphamide (Cytoxan)
2.	Dexamethasone (Maxidex)
3.	Glucocorticoid Receptors (Glucocorticoid Receptor)
4.	Insulin (Novolin)
5.	Immunosuppressive Agents (Immunosuppressants)
6.	Methotrexate (Mexate)
7.	Hydrocortisone (Cortisol)
8.	Steroids
9.	Prednisolone (Predate)
10.	Cyclosporine (Ciclosporin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Injections
3.	Radiotherapy
4.	Intra-Articular Injections
5.	Heterologous Transplantation (Xenotransplantation)