[Progress of berberine for treatment of type 2 diabetes].

Abstract

Berberine is the major component of Coptidis Rhizoma and it has been used as anti-infection, anti-inflammation drug for gastrointestinal diseases. In recent years, evidence showed that it could regulate glucose and lipid metabolism. Moreover, its activity had been tested by clinical trials and animal researches. The mechanisms of berberine in diabetes include: improving the function of beta-cell; prompting insulin secretion and islets regeneration, lowing lipid level, regulating glucose and lipid metabolic by influence transcriptional factors expression such as PPARgamma, C/EBPalpha, SREBP-1c, LXR, having the activities of anti-oxidation and inhibiting reductase to repress oxidative stress state and regulate metabolic signal pathway. Although numbers of data supported that berberine could improving insulin resistance by clinical trials and animal studies, the large scale, multicenter clinical trials are needed to evaluate the effects of berberine for diabetes and its complications in the time of evidence-based medicine.

• Authors: Xiao-Wei Deng, Ning Xie
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 39 Issue 8 Pg. 1374-8 (Apr 2014) ISSN: 1001-5302 [Print] China
• PMID: 25039167 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Hypoglycemic Agents
• Insulin
• Berberine
• Glucose

Topics

• Animals
• Berberine (adverse effects, therapeutic use)
• Diabetes Mellitus, Type 2 (drug therapy, genetics, metabolism)
• Glucose (metabolism)
• Humans
• Hypoglycemic Agents (adverse effects, therapeutic use)
• Insulin (metabolism)
• Lipid Metabolism (drug effects)