PPAR gamma

A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.

Also Known As:

Networked: 3895 relevant articles (244 outcomes, 687 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kadowaki, Takashi: 25 articles (02/2010 - 01/2002)
2.	Safe, Stephen: 23 articles (06/2010 - 03/2003)
3.	Nakajima, Atsushi: 22 articles (01/2010 - 07/2002)
4.	Thiemermann, Christoph: 21 articles (08/2010 - 05/2002)
5.	Wada, Koichiro: 19 articles (02/2010 - 07/2002)
6.	Auwerx, Johan: 19 articles (02/2010 - 01/2002)
7.	Staels, Bart: 19 articles (06/2008 - 05/2002)
8.	Phipps, Richard P: 18 articles (01/2013 - 01/2002)
9.	Gonzalez, Frank J: 18 articles (02/2010 - 05/2002)
10.	Heneka, Michael T: 17 articles (01/2012 - 06/2002)

Related Diseases

1.	Insulin Resistance 10/01/2003 - "Indeed, pharmacological inhibitors of PPARgamma/RXR ameliorates high-fat diet-induced insulin resistance in animal models of type 2 diabetes." 07/15/2004 - "Recent data have shown that peroxisome proliferator-activated receptor-gamma agonists may exert protective effects on the vascular endothelium by amelioration of insulin resistance and through direct anti-inflammatory effects. " 07/22/2010 - "All these findings strongly suggest that Cdk5-mediated phosphorylation of PPARgamma may be involved in the pathogenesis of insulin-resistance, and present an opportunity for development of an improved generation of anti-diabetic drugs through PPARgamma." 06/15/2009 - "They acted as full or partial PPARgamma agonist, or improved insulin resistance through non-PPARgamma pathway." 04/01/2008 - "We used a loss-of-function approach to investigate whether ABA ameliorates insulin resistance through a mechanism dependent on immune cell PPARgamma. "
2.	Inflammation 12/01/2004 - "Although PPARgamma expression is generally low in the CNS, induction of PPARgamma expression during inflammation could be beneficial for inducing Abeta clearance. " 01/15/2000 - "Our data suggest that compounds capable of activating PPARgamma in leukocytes will not be useful for the treatment of acute inflammation." 01/01/2010 - "In parallel to the reduction of AT-inflammation, ligand-activated PPARgamma improved diet-induced IR and GI. " 06/01/2005 - "Agonists of the peroxisome proliferator-activated receptor-gamma may help to regulate inflammation by modulating the production of inflammatory mediators and adhesion molecules. " 04/02/2001 - "A role for the RXR/PPARgamma heterodimer in the protection against colon inflammation was explored by the use of selective RXR and PPARgamma agonists. "
3.	Neoplasms (Cancer) 03/01/2008 - "Thus, BAG-1 is unlikely to directly modulate PPARgamma function, but the overexpression of BAG-1 in some breast cancers may limit the efficacy of PPARgamma agonists as cancer therapies, by suppression of PPARgamma-induced cell death pathways." 03/01/2015 - "In this study, we demonstrated that MH induces apoptosis in SiHa cervical cancer cells by enhancing peroxisome proliferator-activated receptor-gamma (PPARγ) activation, followed by inhibition of the PI3K/Akt pathway and intrinsic pathway induction. " 01/01/2014 - "Several studies have investigated polymorphisms in the peroxisome proliferator-activated receptor gamma (PPARγ) gene and NSAID use in association with cancer risk. " 10/01/2012 - "Recent studies suggest that peroxisome proliferator-activated receptor gamma (PPARγ) agonists may have cancer chemopreventive activity. " 01/01/2012 - "Whereas early studies have yielded variable conclusions regarding the prevalence of PPARgamma mutations in cancer, the protein level of this receptor has been more recently identified as a significant prognostic marker. "
4.	Atherosclerosis 05/01/2006 - "Recent studies have indicated that in addition to antidiabetic properties, PPAR-gamma activators may also provide protection against atherosclerosis and coronary events. " 12/21/2004 - "Multiple experimental studies have documented plaque stabilization with PPAR-gamma agonists, a group of medications holding great promise in the treatment of diabetes atherosclerosis." 01/01/2010 - "Several studies suggest that the peroxisome proliferator-activated receptor gamma (PPARγ) is involved in atherogenesis. " 12/19/2003 - "This study aims to identify other metalloproteinase genes of the ADAM (A Disintegin And Metalloproteinase) and ADAMTS families that are regulated by PPAR gamma or RXR agonists, which are potentially important in type 2 diabetes and/or related atherosclerosis. " 10/01/2003 - "In this study, the association of the Pro12Ala peroxisome proliferator-activated receptor gamma2 (PPARgamma2) polymorphism with atherosclerosis was examined in a Japanese Type 2 diabetic population. "
5.	Hypertension (High Blood Pressure) 01/01/2009 - "We suggest that downregulation of PPARgamma but upregulation of GRK-2 increases blood pressure and impaired renal vascular reactivity in SHR and that PPARgamma-mediated improvement in hypertension may involve transcriptional regulation of GRK-2 function." 11/01/2010 - "To study the relationship between PPARgamma2 Pro12Ala polymorphism and cognitive function in patients with primary hypertension. " 01/01/2009 - "In this study we investigated the role of GRK-2 in PPARgamma-mediated blood pressure regulation in hypertension. " 12/01/2008 - "The Pro12Ala polymorphism of PPAR gamma 2 has been shown to influence hypertension and the benefit of longevity in previous studies. " 05/01/2005 - "We randomly recruited 251 nuclear families (433 parents and 493 offspring) in the framework of the European Project on Genes in Hypertension study and genotyped 926 participants in whom all serum lipid variables and information on alcohol consumption were available for PPARgamma2 Pro12Ala. "

Related Drugs and Biologics

1.	PPAR gamma
2.	Ligands
3.	Insulin (Novolin)
4.	rosiglitazone (Avandia)
5.	pioglitazone (Actos)
6.	Thiazolidinediones
7.	PPAR alpha
8.	2,4-thiazolidinedione (thiazolidinedione)
9.	Glucose (Dextrose)
10.	troglitazone (Rezulin)

Related Therapies and Procedures

1.	Chemoprevention
2.	Oral Administration
3.	Heterologous Transplantation (Xenotransplantation)
4.	Peritoneal Dialysis
5.	Homologous Transplantation (Allograft)