Abstract | BACKGROUND: MATERIALS AND METHODS: In this cross sectional descriptive study,10 patients (lower than 18 y/o)with transfusion dependent thalassemia attending to Motahari and Emam Khomeini hospitals in Urmia city of Iran were enrolled and scanned for Bone Mineral Density (BMD) starting at around 10 years old. RESULTS: Tenatients (6 male and 4 female) with transfusion dependent thalassemia (β- thalassemia major and intermedia) aged 13to 17 years in Urmia city of Iran were enrolled. Mean age of patients was 15.1±.37year old. Among them, 8 patients (80%)had low BMD and2 of them (20%) had normal BMD in lumbar spine. Only 30% of patients had low BMD in the neck of femur. CONCLUSION: We should perform annual BMD in patients with thalassemia major and intermedia and hemoglobin H disease in age of higher than 8 year old and treat low BMD with administration of bisphosphonate, calcium and vitamin D supplements. Medical consultation with a rheumatologist and /or an endocrinologist should be performed in these patients. Changing lifestyle with mild daily exercise, adequate calcium containing foods, avoiding heavy activities, stop smoking, iron chelation therapy in adequate dosage, early diagnosis and treatment of endocrine insufficiency and regular blood transfusions can help to achieve an optimal bone density in these patients.
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Authors | N Valizadeh, F Farrokhi, V Alinejad, Sm Said Mardani, N Valizadeh, S Hejazi, M Noroozi |
Journal | Iranian journal of pediatric hematology and oncology
(Iran J Ped Hematol Oncol)
Vol. 4
Issue 2
Pg. 68-71
( 2014)
ISSN: 2008-8892 [Print] Iran |
PMID | 25002928
(Publication Type: Journal Article)
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