Chelation Therapy (Therapy, Chelation)

Therapy of heavy metal poisoning using agents which sequester the metal from organs or tissues and bind it firmly within the ring structure of a new compound which can be eliminated from the body.

Also Known As:

Networked: 943 relevant articles (97 outcomes, 90 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Porter, John B: 19 articles (02/2015 - 07/2004)
2.	De Sanctis, Vincenzo: 14 articles (03/2015 - 12/2004)
3.	Taher, Ali T: 10 articles (01/2015 - 01/2009)
4.	Cappellini, Maria Domenica: 10 articles (01/2015 - 05/2007)
5.	Musallam, Khaled M: 9 articles (02/2015 - 01/2009)
6.	Habr, Dany: 9 articles (02/2015 - 06/2009)
7.	Gattermann, Norbert: 8 articles (10/2015 - 12/2007)
8.	Maggio, Aurelio: 8 articles (08/2015 - 03/2002)
9.	Lamas, Gervasio A: 8 articles (05/2015 - 03/2013)
10.	Taher, Ali: 8 articles (07/2014 - 07/2006)

Related Diseases

1.	Iron Overload 01/01/2009 - "The cumulative effects of iron overload cause significant morbidity and mortality if not effectively treated with chelation therapy. " 12/01/2001 - "The decrease in iron overload observed in patients on close follow up implies that compliance with chelation therapy has improved with time and therefore, a favourable influence in survival could be expected." 01/01/1999 - "The procedure is safe and effective in reducing iron overload and can obviate the need for chelation therapy, even when the target Hb S is maintained at the standard 30% range." 04/01/1995 - "The ability to quantitate transfusional iron overload is crucial for determining the need for and the efficacy of chelation therapy in patients with long-standing transfusion-dependent anaemias. " 01/01/1985 - "Chronic transfusion has become practicable since the recent advances in chelation therapy have essentially eliminated the risk of secondary iron overload."
2.	beta-Thalassemia (Cooley's Anemia) 02/01/2005 - "Hypertransfusion and regular chelation therapy have allowed improved survival in patients with thalassemia major (TM). " 11/01/2013 - "Our study included 33 patients diagnosed with beta-thalassemia major who were treated with regular transfusions and chelation therapy. " 10/01/2004 - "All available radiographs and MRI studies of the knees in 14 beta-thalassemia major patients (mean age, 16.3 years; age range, 7-33 years) undergoing chelation therapy with L1 were retrospectively assessed for changes in the synovium, cartilage, and bone. " 01/01/1991 - "This study examined anterior pituitary function and the effect of chelation therapy in 31 patients with beta-thalassemia/HbE disease. " 06/01/2015 - "Impact of educational programme regarding chelation therapy on the quality of life for B-thalassemia major children."
3.	Thalassemia 01/01/2008 - "Effects of chelation therapy on cardiac function improvement in thalassemia patients: literature review and the Taiwanese experience." 03/01/2014 - "Eighty-nine β-thalassemia patients receiving chelation therapy (mean age of 20.8 ± 6.4 years) were recruited in this study. " 06/01/2015 - "Application of educational programmes for thalassemic children and their nurses regarding chelation therapy and its importance in preventing thalassemia complications is established. " 06/01/2015 - "The researcher used a predesigned interviewing questionnaire to collect data regarding children's knowledge about thalassemia and its management, especially regarding chelation therapy. " 01/01/2015 - "Comparison of Blood Transfusion Plus Chelation Therapy and Bone Marrow Transplantation in Patients with β-Thalassemia: Application of SF-36, EQ-5D, and Visual Analogue Scale Measures."
4.	Lead Poisoning (Poisoning, Lead) 03/01/1997 - "In summary, LXRF estimates of Pb in tibial cortical bone have yielded highly relevant clinical data relating to the efficacy of chelation therapy with CaNa2EDTA in lead poisoned children; diagnostic approach(es) to childhood lead poisoning; and evaluations of exposure in children, teenagers, and adults in lead-exposed and non-lead-exposed suburban communities. " 01/01/1988 - "Two children with lead poisoning had delayed conduction in the peripheral pathways only and in these there was good correlation between the degree of delay and the ulnar nerve conduction velocity; both improved after chelation therapy. " 09/01/1991 - "Although both patients improved with several months of intramuscular chelation therapy, the efficacy of such therapy in chronic lead poisoning is controversial. " 01/01/2015 - "Standard chelation therapy in different groups and up-to-date less toxic new medications for the treatment of lead poisoning are finally discussed. " 04/01/2012 - "Our goal was to determine the cause of the childhood lead poisoning outbreak, investigate risk factors for child mortality, and identify children < 5 years of age in need of emergency chelation therapy for lead poisoning. "
5.	Poisoning 03/01/1984 - "Therefore, it appears that MT does not play an important role in the acute decrease in efficacy of chelation therapy for Cd poisoning. " 05/01/1983 - "Therefore, if appears that MT does not have an important role in the acute decrease in efficacy of chelation therapy for Cd poisoning. " 02/01/1996 - "Even though there is no doubt that chelation therapy has significantly contributed to reduce mortality and morbidity from occupational Pb poisoning, the efficacy of this treatment in subjects with subtle neurological or renal damage has not yet been studied properly." 01/01/2009 - "The chelation therapy cycles showed great efficacy during symptomatic periods, thus reducing the symptoms and signs of poisoning and promoting great amounts of lead excretion, thereby reducing the total lead burden responsible for the symptoms. " 07/01/2006 - "In nine patients of poisoning group, CSF-Hg concentrations were correlated with B-Hg (r = 0.675, P < 0.05), but not U-Hg. After chelation therapy with dimercaptopropane sulfonate in five patients of poisoning group, the levels of B-Hg, U-Hg, and CSF-Hg were decreased significantly (P < 0.05). "

Related Drugs and Biologics

1.	Iron
2.	Deferoxamine (Desferal)
3.	Edetic Acid (EDTA)
4.	deferasirox
5.	deferiprone (CP20)
6.	Ferritins (Ferritin)
7.	Penicillamine (Cuprimine)
8.	Chelating Agents
9.	Sodium
10.	Aluminum

Related Therapies and Procedures

1.	Blood Transfusion (Blood Transfusions)
2.	Transplants (Transplant)
3.	Transplantation (Transplant Recipients)
4.	Erythrocyte Transfusion
5.	Splenectomy