Metabolic Bone Diseases (Osteopenia)

02/01/1998 - "In summary, this study demonstrated that alendronate therapy is highly effective in counteracting the osteopenia of OVX and glucocorticoid therapy."
07/01/2013 - "Treatment with alendronate sodium may be effective in alleviating osteopenia."
01/01/2007 - "In women with osteopenia, alendronate therapy may be cost effective in women with a T-score of -2.4SD in the US. "
12/01/2005 - "Is alendronate therapy cost-effective for postmenopausal osteopenia?"
05/01/2009 - "Alendronate infused in this manner significantly prevented the osteopenia that critically began early in the consolidation phase, though the dose used in this study was relatively low and no adverse events were noted."

01/01/1981 - "Research over the last fifteen years has led to the identification of several metabolites of vitamin D, elucidation of their mechanism of action, clarification of the pathogenesis of several metabolic bone diseases, and development of new diagnostic tests and more effective and safe treatment. "
01/01/1980 - "It is therefore suggested that administration of active vitamin D metabolites is an effective protection against one of the pathogenic mechanisms of steroid induced osteopenia."
01/11/2014 - "We included all randomised trials comparing interventions that differed only in vitamin D content, and which included adults (average age >20 years) without other metabolic bone diseases. "
01/01/2014 - "Prophylactic effect of low dose vitamin D in osteopenia of prematurity: a clinical trial study."
09/01/2012 - "This study investigated the prevalence of vitamin D insufficiency and deficiency and other secondary causes of low bone density in patients who have sustained a fragility fracture and were referred from fracture clinic to a metabolic bone disease clinic (MBDC) for further assessment. "

07/25/2003 - "In addition, the 0.30 mg/day of CEE, in addition to a proper calcium supplementation, irrespective of the progestin used, can provide effective protection against activation of bone turnover and femur osteopenia."
03/01/1995 - "Our results indicate that natural calcium is effective in prevention of osteopenia in ovariectomized rats. "
10/01/2006 - "Supplemental feeding of DFAIII partly prevents postgastrectomy osteopenia as a result of an improvement in calcium absorption. "
10/01/2000 - "Early detection of osteopenia and improvement in general measures for adequate bone mass peaking (calcium intake and physical activity) should be considered mandatory in the health care of these patients."
08/01/2010 - "Generally, the study found that women with osteopenia had higher levels of bone turnover markers, less lean body mass and lower calcium intake than women with normal BMD. "

08/01/1988 - "Our results indicate that estrogen treatment provides complete protection against osteopenia in OVX rats. "
11/01/1995 - "To determine if the beneficial effects of PTH therapy can be preserved by estrogen alone and whether PTH therapy can be effective in treating osteopenic subjects stabilized with estrogen, we have undertaken a "crossover" study in the rat model of estrogen-deficiency induced osteopenia. "
11/01/1995 - "We have reported previously that combined treatment with PTH and estrogen in estrogen-deficient rats was beneficial in correcting established osteopenia. "
09/01/2003 - "injection markedly increases bone formation and may be a useful treatment for cancellous osteopenia in the estrogen-deplete skeleton. "
04/01/1991 - "These findings indicate that diphosphonate compounds and estrogen provide long-term protection against tibial and vertebral osteopenia in OVX rats. "

01/01/2007 - "We identified 11 studies investigating bisphosphonates in women with low bone mineral density (BMD) [T-score >2.5 standard deviations {SDs} below normal {mean} peak values for young adults] and previous fractures, five studies investigating bisphosphonates in women with low BMD and no previous fracture, one study of bisphosphonates in women with osteopenia, five studies involving screening and two studies of bisphosphonates in special populations (women initiating corticosteroid treatment and men). "
06/01/2014 - "This case series consisted of three patients with BRONJ following the use of bisphosphonates (BPs); for metastatic and metabolic bone diseases, none responded to conservative treatment. "
04/01/2014 - "Patients who were taking bisphosphonates or who had a history of inflammatory, infectious, or metabolic bone disease and previous hip and knee surgery were excluded. "
01/01/2012 - "Bisphosphonates are anticatabolic agents that have been widely used to treat a variety of metabolic bone diseases. "
04/01/2011 - "Bisphosphonates (BPs), the synthetic analogues of pyrophosphate, are widely used in the treatment of metabolic bone diseases. "

02/01/2015 - "In a secondary analysis of a double-blind, placebo-controlled trial in which early post-menopausal women (N=1054) with normal bone density or osteopenia were randomized to infusion of zoledronate 5 mg (N=703) or placebo (N=351), we analyzed significant adverse ocular events occurring within 3 months. "
09/01/2013 - "We performed a multicenter, phase II, randomized open-label trial of intravenous zoledronic acid (ZA) to prevent BMD loss in adult recipients of alloHCT with osteopenia before HCT. "
10/01/2010 - "In order to determine the duration of the antiresorptive action of a single 5-mg dose of intravenous zoledronate, we conducted a 3-year double-blind, randomized, placebo-controlled trial in a volunteer sample of 50 postmenopausal women with osteopenia. "
05/01/2008 - "The hypothesis tested in this study was that perioperative administration of the bisphosphonate zoledronate will reduce strain protection-related calcar osteopenia and maintain functional integration of the femoral component in an ovine hemiarthroplasty model. "
07/01/2003 - "In this study of 30 rabbits, zoledronic acid increased regenerate volume, mineralization, and tibial strength and prevented osteopenia over a 6-week period. "

07/01/2010 - "These phenotypic features of osteopenia are similar to those observed in OI type I. In this study, we investigated whether administration of the third-generation bisphosphonate risedronate (RIS) is effective for treating osteopenia in OASIS-/- mice. "
05/01/2008 - "This posthoc analysis of four trials studied the efficacy of risedronate to reduce fragility fractures in postmenopausal women with osteopenia (i.e., T-scores between -1 and -2.5). "
09/01/2007 - "Effects of risedronate 5 mg/d on bone mineral density and bone turnover markers in late-postmenopausal women with osteopenia: a multinational, 24-month, randomized, double-blind, placebo-controlled, parallel-group, phase III trial."
11/01/2015 - "Physical activity and risedronate sodium have effects on metabolic bone diseases, maintaining the integrity of bone tissue. "
04/01/2015 - "Risedronate (Actonel©) is a bisphosphonate used for the treatment of osteopenia. "

09/01/2015 - "This study investigated the correlations among BMD, nutrient intake, basal physical fitness and serum markers in elderly women with osteopenia. "
04/01/2007 - "An elevated dialysate Ca concentration is required in NHD to prevent osteopenia but differences in serum markers of mineral metabolism between 1.5 and 1.75 mmol/L Ca dialysate in NHD in our study were few. "
07/01/1996 - "The results of this study contribute to the establishment of reference values in normal children for these biochemical assays; these reference values are needed when the above biological markers will be applied in the monitoring of metabolic bone diseases."
10/01/2015 - "All-cause and cause-specific mortality and hospitalization, laboratory markers of metabolic bone disease, and drug utilization. "
09/01/2015 - "Characteristics of nutrient intakes, basal physical fitness and serum markers in elderly women with osteopenia."

01/01/1998 - "These results indicate that 17 beta-estradiol is particularly effective at preventing high-turnover-induced osteopenia in 30-month-old animals."
08/01/2000 - "To test our hypothesis, fourteen community-dwelling men with osteopenia of the femoral neck were treated for 9 weeks with micronized estradiol, 1 mg/d, a dose which is effective in postmenopausal women. "
03/14/2014 - "In the present study, we determined whether Res prevents oestrogen deficiency-induced osteopenia and whether Res administration decreases pathological changes in the endometrium and lumen of the uterus compared with oestradiol replacement therapy (ERT). "
03/01/1992 - "This study investigated whether 17 beta-estradiol replacement could influence the development of osteopenia in the oophorectomized rat treated with CsA. "
09/01/2006 - "This decreased response, especially to estradiol, may be a major cause of the osteopenia observed in diabetes."

10/01/2013 - "Prevention of postoperative osteopenia using IV pamidronate: a pilot study."
07/01/2013 - "Our patient showed no abnormalities at birth, frequent fractures, osteopenia, and poor response on pamidronate therapy. "
01/01/2012 - "However, little research has been done on pamidronate infusion in the home health setting for patients with metabolic bone disease. "
01/01/2011 - "In this 12-month, randomized, double-blind, multicenter trial, 39 kidney recipients with diagnosed osteopenia received two doses of 30 mg of disodium pamidronate (n = 24) or placebo (n = 15), at surgery and 3 months post-RT. "
09/01/2006 - "Low doses of pamidronate for the treatment of osteopenia in non-ambulatory children."

08/01/2015 - "This study provided evidence that ovariectomy-induced osteopenia impair the middle and late bone healing process. "
01/01/2014 - "The aims of this study were to evaluate the osteoprotective effect of aqueous extract from Rhizoma Dioscoreae (RDE) on rats with ovariectomy- (OVX-) induced osteopenia. "
10/01/2010 - "This study describes a method for inducing osteopenia using bilateral ovariectomy (OVX), which causes significant changes in bone mineral density (BMD) in rats. "
01/01/2005 - "To study the involvement of nerve fibers in the regulation of bone remodeling, we have evaluated the modifications of innervation in a classical in vivo model of osteopenia in rats, ovariectomy (OVX). "
10/01/2001 - "Although ovariectomy produces significant trabecular bone loss after 2 weeks, long-term glucocorticoid treatment has been reported to cause osteopenia in some studies but not in others. "

01/01/1983 - "Preoperative intact PTH levels were strongly predictive of clinical response to subtotal parathyroidectomy, and may help to differentiate the nature of metabolic bone disease in symptomatic dialysis patients. "
11/01/1996 - "We conclude that parathyroidectomy markedly improves lumbar spine BMD in patients with vertebral osteopenia. "
08/01/1993 - "Univariate analysis and stepwise regression analysis demonstrated radiographic evidence of osteopenia (beta-coefficient = -0.180 +/- 0.050; P = 0.001) and prior parathyroidectomy (beta-coefficient = 0.133 +/- 0.070; P = 0.054) as the only variables significantly correlated to the BMD. "
04/01/1977 - "Influence of age, metabolic bone disease, and parathyroidectomy."
06/03/1977 - "In these patients subtotal parathyroidectomy gave satisfactory results, but the treatment of renal osteopathy in the sense of osteopenia is often unsatisfactory and the full clinical picture can often be improved only by early renal transplantation."

10/01/2006 - "Internal fixation of two-part, three-part, and selected four-part fractures may be compromised by local osteopenia; knowledge of the location of the strongest bone in the proximal humerus combined with the use of fixed-angle devices and occasionally bone graft or substitutes has improved the outcome of osteosynthesis. "
09/01/2012 - "Despite diffuse osteopenia and chronic immunosuppression in renal transplant patients with osteonecrotic hips, cementless THA showed durable implant fixation to bone and no increased risk of complications."
01/01/2012 - "The immediate post-operative bone loss after LT can be significantly avoided by pre-treatment of liver transplant candidates affected by osteopenia."
01/01/2012 - "The bone mineral density (BMD) of the lumbar spine (LS) and the femoral neck was measured prospectively pre- and post-LT in 31 patients with existing pre-transplant osteopenia. "
12/01/2007 - "Osteopenia determined by lumbar spine BMD underestimates poor BMD in our population of young adults after liver transplant. "

04/01/2006 - "The aim of this study was to investigate the markers of metabolic bone disease and peritoneal clearance of these markers in children treated with continuous ambulatory peritoneal dialysis (CAPD). "
01/01/1996 - "We conclude that the prevalence of osteopenia is not increased in CAPD patients. "
06/01/1987 - "When patients undergoing continuous ambulatory peritoneal dialysis or hemodialysis and receiving similar treatment for renal osteodystrophy were compared, patients treated with continuous ambulatory peritoneal dialysis appeared to have a greater improvement in their metabolic bone disease."
04/01/2006 - "In conclusion, Clp-osteocalcin is of no interest as a non-invasive marker of metabolic bone disease in children treated with CAPD. "
09/01/1994 - "Osteocalcin: a non-invasive index of metabolic bone disease in patients treated by CAPD."

08/01/2004 - "Osteopenia is very prevalent in adult transplant recipients and probably also in pediatrics, but its occurrence and sequelae are difficult to study in these groups due to methodological shortfalls of planar densitometry related to short stature and altered patterns of growth and development. "
12/15/1994 - "Results of this study indicate that posttransplant osteopenia is common in renal transplant recipients, including those treated with CsA. "
10/06/2015 - "MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus."
06/01/2013 - "Most potential CF recipients have metabolic bone disease warranting treatment, especially with the significant loss of bone density seen in the first year after transplantation. "
01/01/2013 - "Osteopenia is a common systemic manifestation in patients with IPF in the pre-transplantation period. "