Abstract | AIMS: The aim of our study was to evaluate the relationship between insulin resistance and the detection of precocious echocardiographic signs of heart failure in patients with cardiovascular risk factors. METHODS: RESULTS: Distinguishing patients with insulin resistance, based on the median value of HOMA-IR (<4.06 and >4.06), we observed that in the group with higher levels of HOMA-IR, there were echocardiographic signs of subclinical ventricular dysfunction statistically more frequent (E/A in group with HOMA <4.06: 1.159 + 0.33 vs. group with HOMA >4.06: 0.87 + 0.29, P = 0.0136; E/E': 6.42 + 4 vs. 15.52 + 3.26, P = 0.001; Tei index: 0.393 + 0.088 vs. 0.489 + 0.079, P = 0.0029; S wave: 0112 + 0.015 vs. 0.114 + 0.027, P = 0.0001; ejection fraction 59.11 + 4.75 vs. 58.88 + 6.81, P = 0.9078). Grade II diastolic dysfunction was observed in 5 patients, grade I in 12 patients, and 17 patients had normal diastolic function. On multivariate analysis, HOMA-IR (P = 0.0092), hypertension (P = 0.0287), waist circumference (P = 0.0009), high-density lipoprotein (P = 0.0004), and fasting blood glucose (P = 0.0003) were variables independently associated with diastolic dysfunction. On analysis of covariance, we found that the variables that influence diastolic dysfunction are HOMA-IR, waist circumference, BMI, and age, and that the only variable that influences Tei index is HOMA-IR. CONCLUSION:
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Authors | Giuseppina Novo, Marinella Pugliesi, Claudia Visconti, Pietro Spatafora, Marianna Fiore, Riccardo Di Miceli, Francesco Paolo Guarneri, Giustina Vitale, Salvatore Novo |
Journal | Journal of cardiovascular medicine (Hagerstown, Md.)
(J Cardiovasc Med (Hagerstown))
Vol. 15
Issue 2
Pg. 110-4
(Feb 2014)
ISSN: 1558-2035 [Electronic] United States |
PMID | 24522082
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Blood Glucose
- Insulin
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Topics |
- Aged
- Asymptomatic Diseases
- Biomarkers
(blood)
- Blood Glucose
(metabolism)
- Female
- Heart Failure
(diagnostic imaging, etiology, physiopathology)
- Humans
- Insulin
(blood)
- Insulin Resistance
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Pilot Projects
- Predictive Value of Tests
- Risk Assessment
- Risk Factors
- Ultrasonography
- Ventricular Dysfunction, Left
(diagnostic imaging, etiology, physiopathology)
- Ventricular Function, Left
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