Anti-wrinkle and anti-inflammatory effects of active garlic components and the inhibition of MMPs via NF-κB signaling.

Abstract

Skin aging is a multisystem degenerative process caused by several factors, such as, UV irradiation, stress, and smoke. Furthermore, wrinkle formation is a striking feature of photoaging and is associated with oxidative stress and inflammatory response. In the present study, we investigated whether caffeic acid, S-allyl cysteine, and uracil, which were isolated from garlic, modulate UVB-induced wrinkle formation and effect the expression of matrix-metalloproteinase (MMP) and NF-κB signaling. The results obtained showed that all three compounds significantly inhibited the degradation of type І procollagen and the expressions of MMPs in vivo and attenuated the histological collagen fiber disorder and oxidative stress in vivo. Furthermore, caffeic acid and S-allyl cysteine were found to decrease oxidative stress and inflammation by modulating the activities of NF-κB and AP-1, and uracil exhibited an indirect anti-oxidant effect by suppressing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expressions levels and downregulating transcriptional factors. These results suggest that the anti-wrinkle effects of caffeic acid, S-allyl cysteine, and uracil are due to anti-oxidant and/or anti-inflammatory effects. Summarizing, caffeic acid, S-allyl cysteine, and uracil inhibited UVB-induced wrinkle formation by modulating MMP via NF-κB signaling.

• Authors: So Ra Kim, Yu Ri Jung, Hye Jin An, Dae Hyun Kim, Eun Ji Jang, Yeon Ja Choi, Kyoung Mi Moon, Min Hi Park, Chan Hum Park, Ki Wung Chung, Ha Ram Bae, Yung Whan Choi, Nam Deuk Kim, Hae Young Chung
• Journal: PloS one (PLoS One) Vol. 8 Issue 9 Pg. e73877 ( 2013) ISSN: 1932-6203 [Electronic] United States
• PMID: 24066081 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Caffeic Acids
• NF-kappa B
• Uracil
• S-allylcysteine
• Matrix Metalloproteinases
• Cysteine
• caffeic acid

Topics

• Animals
• Anti-Inflammatory Agents (chemistry, therapeutic use)
• Caffeic Acids (therapeutic use)
• Cysteine (analogs & derivatives, therapeutic use)
• Garlic (chemistry)
• Male
• Matrix Metalloproteinases (metabolism)
• Mice
• NF-kappa B (metabolism)
• Oxidative Stress (drug effects)
• Signal Transduction (drug effects, radiation effects)
• Skin Aging (drug effects, radiation effects)
• Ultraviolet Rays
• Uracil (therapeutic use)