Transcription Factor AP-1 (Transcription Factor AP 1)

A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.

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Networked: 2147 relevant articles (25 outcomes, 213 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Colburn, Nancy H: 18 articles (01/2012 - 06/2002)
2.	Tang, Chih-Hsin: 16 articles (01/2014 - 09/2007)
3.	Wagner, Erwin F: 15 articles (07/2015 - 03/2002)
4.	Surh, Young-Joon: 12 articles (05/2013 - 05/2002)
5.	Young, Matthew R: 12 articles (01/2012 - 06/2002)
6.	Dong, Zigang: 10 articles (05/2013 - 01/2003)
7.	Rahman, Irfan: 10 articles (11/2006 - 05/2002)
8.	Brown, Powel H: 9 articles (02/2009 - 10/2002)
9.	Dong, Z: 9 articles (11/2004 - 01/2000)
10.	Bode, Ann M: 8 articles (05/2013 - 08/2005)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2008 - "However, this regulation was dramatically reduced in tumor cells and completely abolished in primary cells transfected with an HO-1 promoter construct containing mutations in both the E-box and the AP-1 site, suggesting that AP-1 factors and USF-2 may act in a cooperative manner. " 06/01/2011 - "We observed a significant inhibition of UVB-induced AP-1 activation and COX-2 expression in p38DN transgenic mice, leading to a significant reduction of UVB-induced tumor number and growth compared to wild-type littermates in a chronic UVB skin carcinogenesis model. " 02/01/2007 - "Identification of novel and specific AP-1 inhibitors would be beneficial for cancer prevention and therapy. " 10/01/2012 - "The study presented here further reveals in detail the mechanism of how Pdcd4 inhibits tumor cell invasion and provides a functional connection between β-catenin/Tcf and AP-1 dependent transcription." 01/01/2012 - "The tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) activates a variety of signaling pathways, including MAPK/AP-1. In this study, we examined the time course of EGFR phosphorylation and AP-1 activation in mouse epidermis after topical application of a single 10 nmol dose of TPA. "
2.	Inflammation 08/15/2013 - "Taken together, this study identifies a novel signaling mechanism mediated by FAT1 in regulating the activity of PDCD4 and thereby the key transcription factor AP-1, which then affects known mediators of neoplasia and inflammation." 05/01/2011 - "Many clinical and experimental studies have shown that inflammation could contribute to ovarian carcinogenesis through activation of the NF-κB and AP-1 pathways by chronic inflammatory mediators. " 08/01/2015 - "The transcription factor AP-1 plays an important role in inflammation and cell survival. " 08/08/2014 - "Taken together, our data suggest that SHQA inhibit TNFα-induced MMP-2/-9 expression and age-related inflammation by suppressing AP-1 and NF-κB pathway via PPARα." 01/01/2014 - "The inflammation-related gene S100A12 is positively regulated by C/EBPβ and AP-1 in pigs."
3.	Prostatic Neoplasms (Prostate Cancer) 11/01/2011 - "These results suggest that Egr-1 may promote prostate cancer development by modulating the activity of factors NF-κB and AP-1, which are involved in cell proliferation and apoptosis." 11/01/2009 - "The importance of AP-1 as a mediator of proliferation and radiation responses is demonstrated by the findings that the expression of JunD, Fra-1 and Fra-2 siRNAs in prostate cancer cells suppress these cellular responses. " 11/01/2009 - "Transcription factor AP-1 promotes growth and radioresistance in prostate cancer cells." 11/01/2009 - "Together, the findings show that AP-1 activity in prostate cancer cells mediates EGF-R and PI3K signalling, is essential for their proliferation, and confers protection against radiation-induced cell death. " 06/01/2002 - "Further studies using Western blot analysis and electrophoresis mobility shift assay (EMSA) revealed that the treatment of prostate cancer cells with specific ODNs activated the caspase pathway(s) and decreased the binding activities of AP-1 and NF-kappaB in a time-dependent manner. "
4.	Lung Neoplasms (Lung Cancer) 01/01/2012 - "LOX-PP reduced expression of Blimp1 by binding to c-Raf and inhibiting activation of AP-1, thereby attenuating the migratory phenotype of lung cancer cells. " 05/17/2002 - "H(2)O(2)-induced AP-1 activation and its effect on p21(WAF1/CIP1)-mediated G2/M arrest in a p53-deficient human lung cancer cell." 08/31/2009 - "These results indicate that Galphas augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 lung cancer cells, suggesting that the efficacy of radiotherapy of lung cancer may be improved by modulating Gs signaling pathway." 01/01/2000 - "Inhibition of AP-1 transcriptional activity may offer improved therapeutic efficacy for lung cancer patients with lymphatic metastasis." 09/08/2015 - "Since AP-1 is implicated in tumor growth and PRDX6 expression, in the present study, we investigated whether SVT inhibits PRDX6, thereby preventing human lung cancer cell growth (A549 and NCI-H460) through inactivation of AP-1. "
5.	Anoxia (Hypoxia) 09/10/2006 - "Another transcription factor, AP-1, was studied for its potential role in the hypoxia-induced protection against apoptosis. " 08/30/2014 - "Although our previous studies showed that SAG is transcriptionally induced by redox, mitogen and hypoxia via AP-1 and HIF-1, it is completely unknown whether and how SAG is ubiquitylated and degraded. " 04/01/2013 - "In conclusion, our study suggests that increased activity of HIF-1α, AP-1 and NF-κB may partly play a significant role in the hepatic response to oxidative stress and liver injury under chronic hypoxia. " 11/01/2005 - "Recent studies have indicated that AP-1 (activator protein-1) regulates CYP2J2 expression in normoxia and hypoxia. " 08/01/2005 - "The review focuses on experimental studies involving cultured cells exposed to hypoxia/anoxia, and describes both established and possible interactions between HIF-1 and AP-1 at different levels of cellular organization."

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)
2.	Transcription Factors (Transcription Factor)
3.	DNA (Deoxyribonucleic Acid)
4.	Interleukin-6 (Interleukin 6)
5.	Phosphotransferases (Kinase)
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Cytokines
8.	Epidermal Growth Factor (EGF)
9.	Retinoids
10.	Antioxidants

Related Therapies and Procedures

1.	Radiotherapy
2.	Immunomodulation
3.	Chemoprevention
4.	Drug Therapy (Chemotherapy)
5.	Injections