Abstract | BACKGROUND AND AIM:
Cholangiocarcinoma arising in the large bile ducts undergoes a multistep carcinogenesis process in chronic biliary diseases, and biliary intraepithelial neoplasia is known as a precursor lesion. This study examined the expression of S100 proteins in the multistep cholangiocarcinogenesis to clarify their clinicopathological significance. METHODS: Immunohistochemical analysis was performed for the expression of S100A2, S100A4, S100A6, and S100P. Bile concentrations of S100P were measured using enzyme-linked immunosorbent assay. RESULTS: CONCLUSIONS: These results suggest that S100P may be useful for the detection of cholangiocarcinoma as tissue and bile biomarkers, and the immunohistochemical expression of S100A2 is a potential prognostic marker in cholangiocarcinoma patients.
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Authors | Yasunori Sato, Kenichi Harada, Motoko Sasaki, Yasuni Nakanuma |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 28
Issue 8
Pg. 1422-9
(Aug 2013)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 23621473
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. |
Chemical References |
- Biomarkers, Tumor
- Chemotactic Factors
- S100 Proteins
- S100A2 protein, human
- lyn protein-tyrosine kinase
- src-Family Kinases
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Topics |
- Bile
(chemistry)
- Bile Duct Neoplasms
(diagnosis, mortality, pathology)
- Biomarkers, Tumor
(analysis)
- Carcinogenesis
(metabolism, pathology)
- Chemotactic Factors
(analysis)
- Cholangiocarcinoma
(diagnosis, mortality, pathology)
- Enzyme-Linked Immunosorbent Assay
- Neoplasm Staging
- ROC Curve
- S100 Proteins
(analysis)
- Sensitivity and Specificity
- Survival Rate
- src-Family Kinases
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