[Visfatin level after laparoscopic Roux-en-Y gastric bypass surgery in patients with Type 2 diabetes].

Abstract

OBJECTIVE:

To investigate the change in serum visfatin level after laparoscopic Roux-en-Y gastric bypass surgery in patients with Type 2 diabetes mellitus (T2DM) and to explore the relationship between visfatin insulin resistance and diabetes.

METHODS:

Thirty-three patients with Type 2 diabetes were studied before and after the gastric bypass surgery. The level of fasting serum visfatin was measured by enzyme-linked immunosorbent assay. Fasting plasma glucose (FPG), glycated hemoglobin (HbA1c) and fasting insulin (FINS) were measured before and after the gastric bypass surgery.

RESULTS:

Compared with before the operation, the indicators of HbA1c, FINS, and insulin resistance index (HOMA-IR) were decreased after the laparoscopic Roux-en-Y gastric bypass surgery. The body mass index (BMI) [(24.53 ± 0.62) kg/m² vs (26.71 ± 0.69) kg/m2] was decreased, with significant difference (P<0.001). The serum visfatin level [(9.79 ± 0.64) ng/mL] was significantly lower than before the operation [(38.24 ± 5.32) ng/mL], with significant difference (P<0.001).

CONCLUSION:

Serum level of visfatin is decreased in T2DM patients who undergo gastric bypass surgry, reflecting an improvement in insulin resistance and diabetes.

• Authors: Yiqun Liu, Jing Xiong, Honghui He, Shaihong Zhu, Zhaohui Mo
• Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban) Vol. 38 Issue 3 Pg. 258-61 (Mar 2013) ISSN: 1672-7347 [Print] China
• PMID: 23545832 (Publication Type: English Abstract, Journal Article)

Chemical References

• Nicotinamide Phosphoribosyltransferase

Topics

• Diabetes Mellitus, Type 2 (blood, surgery)
• Female
• Gastric Bypass
• Humans
• Insulin Resistance
• Laparoscopy
• Male
• Middle Aged
• Nicotinamide Phosphoribosyltransferase (blood)
• Postoperative Period