[A case of interstitial lung disease associated with gemcitabine treatment in a patient with locally advanced pancreatic cancer following proton beam radiotherapy].

Abstract

A 69-year-old woman who had locally advanced pancreatic cancer underwent proton beam radiotherapy(67.5 GyE/25 Fr) concurrent with gemcitabine chemotherapy (GEM 800 mg/m2 day 1, 8) at Hyogo Ion Beam Medical Center, followed by GEM chemotherapy (1,000 mg/m2 day 1, 8, 15/28 day)at Kobe University Hospital. She visited our hospital because she was suffering from dyspnea 212 days after first administration of GEM. A chest computed tomography revealed that infiltrations were spreading in the bilateral lung fields. A bronchoscopy showed diffuse alveolar hemorrhage. We diagnosed GEM related interstitial lung disease with diffuse alveolar hemorrhage. We introduced steroid pulse therapy (methylprednisolone 1 g/day) for 3 days followed by oral prednisolone (40 mg/day), which was tapered gradually. She recovered and was discharged on the 24th day after admission.

• Authors: Masaki Tanaka, Ippei Matsumoto, Makoto Shinzeki, Hirochika Toyama, Sadaki Asari, Tadahiro Goto, Sachiyo Shirakawa, Hironori Yamashita, Hidehiro Sawa, Kimihiko Ueno, Masanori Takahashi, Shinobu Tsuchida, Masahiro Kido, Tetsuo Ajiki, Takumi Fukumoto, Yonson Ku
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 39 Issue 12 Pg. 2158-60 (Nov 2012) ISSN: 0385-0684 [Print] Japan
• PMID: 23268009 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Deoxycytidine
• Gemcitabine

Topics

• Aged
• Antimetabolites, Antineoplastic (adverse effects)
• Deoxycytidine (adverse effects, analogs & derivatives)
• Female
• Hemorrhage (chemically induced)
• Humans
• Lung Diseases, Interstitial (chemically induced)
• Pancreatic Neoplasms (drug therapy, pathology, radiotherapy)
• Proton Therapy (adverse effects)
• Gemcitabine