Abstract |
Bamboo salt (BS) is a specially processed salt according to the traditional recipe using sun-dried salt (SDS) and bamboo in Korea. The present study investigated the effects and mechanism of BS, SDS, NaCl, or mineral mixture (containing zinc, magnesium, and potassium) on ovalbumin (OVA)-induced allergic rhinitis (AR) animal model. The increased number of rubs was inhibited by the oral administration of BS, SDS, NaCl, mineral mixture, or nose inhalation of BS. The increased levels of IgE, histamine, and interleukin (IL)-1β in serum were reduced by BS. The level of interferon-γ was increased, whereas the level of IL-4 was reduced on the spleen tissue of BS-treated mice. In the BS-treated mice, the number of eosinophils and mast cells infiltration increased by OVA-sensitization were also decreased. Protein levels of inflammatory cytokines were reduced by BS or NaCl administration in the nasal mucosa of the AR mice. In addition, BS inhibited caspase-1 activity in the nasal mucosa tissue. In activated human mast cells, BS significantly inhibited the production of IL-1β and thymic stromal lymphopoietin and activation of caspase-1. Our data indicate that BS has anti-allergic and anti-inflammatory effects by regulating of caspase-1 activation in AR mice and in vitro models.
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Authors | Kyu-Yeob Kim, Sun-Young Nam, Tae-Yong Shin, Kun-Young Park, Hyun-Ja Jeong, Hyung-Min Kim |
Journal | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
(Food Chem Toxicol)
Vol. 50
Issue 10
Pg. 3480-8
(Oct 2012)
ISSN: 1873-6351 [Electronic] England |
PMID | 22824089
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Ltd. All rights reserved. |
Chemical References |
- Cytokines
- Sodium Chloride, Dietary
- Immunoglobulin E
- Histamine
- Ovalbumin
- Caspase 1
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Topics |
- Animals
- Bambusa
(chemistry)
- Caspase 1
(metabolism)
- Cell Line
- Cytokines
(genetics, metabolism)
- Food Handling
- Histamine
(metabolism)
- Humans
- Immunoglobulin E
(blood)
- Mast Cells
- Mice
- Nasal Mucosa
- Ovalbumin
(immunology)
- Rhinitis, Allergic
- Rhinitis, Allergic, Perennial
(chemically induced, drug therapy)
- Sodium Chloride, Dietary
(analysis)
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