Interleukin-10 expression during the acute phase is a putative prerequisite for delayed viral elimination in a murine model for multiple sclerosis.

Abstract

Reduced protective immunity leads to viral persistence and demyelination in Theiler's murine encephalomyelitis. The aim of the present study was to compare the phenotype of brain-infiltrating leukocytes and cytokine expression in susceptible SJL and resistant C57BL/6 mice during Theilervirus-induced acute polioencephalitis. In contrast to C57/BL6 mice, SJL mice show an increased number of Foxp3(+) regulatory T cells and CD45R(+) B cells associated with delayed viral elimination and elevated IL-10 mRNA transcripts in the brain. Results substantiate the hypothesis that an imbalanced cytokine milieu during the early infection phase contributes to ineffective antiviral immunity in animals with a susceptible genetic background.

• Authors: Vanessa Herder, Ingo Gerhauser, Stephanie Kristin Klein, Pedro Almeida, Maren Kummerfeld, Reiner Ulrich, Frauke Seehusen, Karl Rohn, Dirk Schaudien, Wolfgang Baumgärtner, Jochen Huehn, Andreas Beineke
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 249 Issue 1-2 Pg. 27-39 (Aug 15 2012) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 22591945 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier B.V. All rights reserved.

Chemical References

• Cytokines
• Forkhead Transcription Factors
• Foxp3 protein, mouse
• IL10 protein, mouse
• RNA, Messenger
• Interleukin-10
• Leukocyte Common Antigens

Topics

• Animals
• B-Lymphocyte Subsets (immunology)
• Brain (immunology, metabolism, virology)
• Cardiovirus Infections (immunology, virology)
• Cytokines (analysis, biosynthesis)
• Disease Models, Animal
• Forkhead Transcription Factors (immunology)
• Gene Expression Regulation
• Immunophenotyping
• Interleukin-10 (biosynthesis, genetics)
• Leukocyte Common Antigens (immunology)
• Mice
• Mice, Inbred C57BL
• Multiple Sclerosis (immunology, virology)
• RNA, Messenger (analysis)
• T-Lymphocyte Subsets (immunology)
• T-Lymphocytes, Regulatory (immunology)
• Theilovirus