The vitamin E derivative, ESeroS-GS, attenuates renal ischemia-reperfusion injury in rats.

Abstract

BACKGROUND:

Acute kidney injury (AKI), which occurs during renal transplantation and cardiovascular surgery, is a major clinical problem associated with high mortality, and has limited treatment options. Anti-inflammation therapy has been suggested to improve the course and outcome of AKI. In this study, we hypothesized that ESeroS-GS, a vitamin E derivative, inhibits cytokine production and prevents renal ischemia-reperfusion (I/R) injury in rats.

METHODS:

Rats received an intravenous infusion of ESeroS-GS or saline, and underwent experimentally-induced renal I/R injury or sham treatment. Rats were sacrificed after 60 min of ischemia and 24 h of reperfusion. To evaluate the renal protective effects of ESero-GS, renal function was examined, kidneys were histologically assessed, levels of myeloperoxidase (MPO) and serum cytokines were measured, and caspase 3/7 activity was determined.

RESULTS:

ESeroS-GS attenuated I/R-induced histologic alterations, reduced levels of MPO and serum BUN, Cre, TNF-α, and IL-6, and decreased caspase 3/7 activity in kidneys of rats subjected to renal I/R injury.

CONCLUSIONS:

ESeroS-GS attenuated renal injury after I/R by reducing serum cytokine levels. Our findings suggest that ESeroS-GS may have therapeutic potential against various human I/R conditions.

• Authors: Hironori Koga, Satoshi Hagiwara, Hideto Mei, Nozomi Hiraoka, Jyunya Kusaka, Koji Goto, Kenji Kashima, Takayuki Noguchi
• Journal: The Journal of surgical research (J Surg Res) Vol. 176 Issue 1 Pg. 220-5 (Jul 2012) ISSN: 1095-8673 [Electronic] United States
• PMID: 22440932 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Benzopyrans
• Indoles
• Interleukin-6
• Tumor Necrosis Factor-alpha
• glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt
• Vitamin E
• Peroxidase
• Caspase 3
• Caspase 7

Topics

• Animals
• Benzopyrans (chemistry, pharmacology, therapeutic use)
• Blood Urea Nitrogen
• Caspase 3 (metabolism)
• Caspase 7 (metabolism)
• Indoles (chemistry, pharmacology, therapeutic use)
• Interleukin-6 (blood)
• Kidney (blood supply, drug effects, metabolism)
• Male
• Models, Animal
• Peroxidase (metabolism)
• Rats
• Rats, Wistar
• Reperfusion Injury (prevention & control)
• Tumor Necrosis Factor-alpha (blood)
• Vitamin E