Abstract | OBJECT: Intracranial surgery causes cortical injury from incisions, hemorrhage, retraction, and electrocautery. The term "surgical brain injury" (SBI) has been developed to categorize this injury inherent to the procedure. Neuroinflammation plays a significant role in SBI. Traditional antiinflammatory therapies are often limited by their immunosuppressive side effects and poor CNS penetration. This study uses mucosal tolerance to develop an immune system that is tolerant to brain myelin basic protein (MBP) so that inflammation can be suppressed in a timely and site-specific manner following surgical disruption of the blood-brain barrier. METHODS: RESULTS: CONCLUSIONS: Developing preoperative immunological tolerance to brain antigens through mucosal tolerance provides neuroprotection, reduces brain edema, and modulates neuroinflammation following SBI.
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Authors | Robert E Ayer, Nazanin Jafarian, Wanqiu Chen, Richard L Applegate 2nd, Austin R T Colohan, John H Zhang |
Journal | Journal of neurosurgery
(J Neurosurg)
Vol. 116
Issue 1
Pg. 246-53
(Jan 2012)
ISSN: 1933-0693 [Electronic] United States |
PMID | 22017304
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Cytokines
- Myelin Basic Protein
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Topics |
- Animals
- Brain
(immunology, metabolism)
- Brain Edema
(immunology, metabolism)
- Brain Injuries
(immunology, metabolism)
- Cytokines
(metabolism)
- Encephalitis
(immunology, metabolism)
- Immune Tolerance
(immunology)
- Immunity, Mucosal
- Mice
- Myelin Basic Protein
(metabolism)
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