Clinical utility of inflammatory markers and advanced lipoprotein testing: advice from an expert panel of lipid specialists.

Abstract

The National Cholesterol Education Program Adult Treatment Panel guidelines have established low-density lipoprotein cholesterol (LDL-C) treatment goals, and secondary non-high-density lipoprotein (HDL)-C treatment goals for persons with hypertriglyceridemia. The use of lipid-lowering therapies, particularly statins, to achieve these goals has reduced cardiovascular disease (CVD) morbidity and mortality; however, significant residual risk for events remains. This, combined with the rising prevalence of obesity, which has shifted the risk profile of the population toward patients in whom LDL-C is less predictive of CVD events (metabolic syndrome, low HDL-C, elevated triglycerides), has increased interest in the clinical use of inflammatory and lipid biomarker assessments. Furthermore, the cost effectiveness of pharmacological intervention for both the initiation of therapy and the intensification of therapy has been enhanced by the availability of a variety of generic statins. This report describes the consensus view of an expert panel convened by the National Lipid Association to evaluate the use of selected biomarkers [C-reactive protein, lipoprotein-associated phospholipase A(2), apolipoprotein B, LDL particle concentration, lipoprotein(a), and LDL and HDL subfractions] to improve risk assessment, or to adjust therapy. These panel recommendations are intended to provide practical advice to clinicians who wrestle with the challenges of identifying the patients who are most likely to benefit from therapy, or intensification of therapy, to provide the optimum protection from CV risk.

• Authors: Michael H Davidson, Christie M Ballantyne, Terry A Jacobson, Vera A Bittner, Lynne T Braun, Alan S Brown, W Virgil Brown, William C Cromwell, Ronald B Goldberg, James M McKenney, Alan T Remaley, Allan D Sniderman, Peter P Toth, Sotirios Tsimikas, Paul E Ziajka, Kevin C Maki, Mary R Dicklin
• Journal: Journal of clinical lipidology (J Clin Lipidol) 2011 Sep-Oct Vol. 5 Issue 5 Pg. 338-67 ISSN: 1933-2874 [Print] United States
• PMID: 21981835 (Publication Type: Consensus Development Conference, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 National Lipid Association. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Cholesterol, LDL
• Hydroxymethylglutaryl-CoA Reductase Inhibitors

Topics

• Biomarkers (blood)
• Cardiovascular Diseases (prevention & control)
• Cholesterol, LDL (blood)
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)
• Hypercholesterolemia (drug therapy)
• Practice Guidelines as Topic
• Risk Assessment