Antinociceptive properties of bergenin.

Abstract

Bergenin (1) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation of cytokine production. The present study was undertaken to evaluate whether 1 has antinociceptive properties in models of inflammatory pain and to investigate its possible mechanisms of action. Pretreatment with 1 (12.5-100 mg/kg, ip) produced a dose-related inhibition of acetic acid-induced writhing in mice. Furthermore, treatment with 1 (50 and 100 mg/kg) inhibited both the early and late phases in a formalin test. In addition, 1 (50 and 100 mg/kg, ip) inhibited mechanical hyperalgesia, edema, and paw production of hyperalgesic cytokines (TNF-α and IL-1β) induced by complete Freund's adjuvant. However, the local production of IL-10, an anti-inflammatory cytokine, was not altered by 1 (100 mg/kg, ip). Treatment with 1 produced a similar profile of antinociception in wild-type and IL-10-deficient mice. Mice treated with 1 did not show any motor performance alterations or apparent systemic toxicity. The results presented herein demonstrate that bergenin has consistent antinociceptive and anti-inflammatory properties, acting by the inhibition of IL-1β and TNF-α production, and suggest its potential for the control of inflammatory pain.

• Authors: Cristiane Metzker de Oliveira, Fabiana Regina Nonato, Flávia Oliveira de Lima, Ricardo David Couto, Juceni P David, Jorge M David, Milena Botelho Pereira Soares, Cristiane Flora Villarreal
• Journal: Journal of natural products (J Nat Prod) Vol. 74 Issue 10 Pg. 2062-8 (Oct 28 2011) ISSN: 1520-6025 [Electronic] United States
• PMID: 21939182 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Anti-Inflammatory Agents, Non-Steroidal
• Benzopyrans
• Tumor Necrosis Factor-alpha
• 3,5-dihydroxy-4-methoxybenzoic acid
• Interleukin-10
• Gallic Acid
• bergenin

Topics

• Analgesics (chemistry, pharmacology)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (chemistry, pharmacology)
• Benzopyrans (chemistry, pharmacology)
• Dose-Response Relationship, Drug
• Edema (chemically induced, drug therapy)
• Gallic Acid (analogs & derivatives, chemistry)
• Interleukin-10 (antagonists & inhibitors, biosynthesis, genetics)
• Male
• Mice
• Pain (chemically induced, drug therapy)
• Pain Measurement
• Tumor Necrosis Factor-alpha (antagonists & inhibitors, biosynthesis)