Abstract | OBJECTIVE: METHODS: RESULTS: Anti-MGO-apoB100 IgM antibody levels were higher in subjects with a low to moderate CAC score (≤400 Agatston units) than in subjects with a high score (>400 Agatston units; 136.8±4.4 vs. 101.6± 7.4 arbitrary units (AU), P<0.0001) and in subjects demonstrating no progression of CAC during 30 months of follow-up (136.4±5.7 vs. 113.9 ± 6.2 AU in subjects with progression, P<0.0001). Subjects with a family history of premature myocardial infarction had lower levels of anti-MGO-apoB100 IgM. Female subjects had higher levels of anti-MGO-apoB100 antibodies and lower CAC than men. Accordingly, high levels of IgM against MGO-apoB100 are associated with less severe and a lower risk of progression of coronary disease in subjects with type 2 diabetes. CONCLUSIONS: Although conclusions regarding causal relationships based on epidemiological observations need to be made with caution, our findings suggest the possibility that anti-MGO-apoB100 IgM may be protective in diabetic vasculopathy.
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Authors | D Engelbertsen, D V Anand, G N Fredrikson, D Hopkins, R Corder, P K Shah, A Lahiri, J Nilsson, E Bengtsson |
Journal | Journal of internal medicine
(J Intern Med)
Vol. 271
Issue 1
Pg. 82-9
(Jan 2012)
ISSN: 1365-2796 [Electronic] England |
PMID | 21668821
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 The Association for the Publication of the Journal of Internal Medicine. |
Chemical References |
- Apolipoprotein B-100
- Autoantibodies
- Immunoglobulin G
- Immunoglobulin M
- Pyruvaldehyde
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Topics |
- Apolipoprotein B-100
(immunology)
- Autoantibodies
(blood)
- Coronary Artery Disease
(blood, epidemiology, etiology)
- Diabetes Complications
(blood, epidemiology)
- Diabetes Mellitus, Type 2
(blood, complications)
- Female
- Humans
- Immunoglobulin G
(blood)
- Immunoglobulin M
(blood)
- Male
- Middle Aged
- Pyruvaldehyde
- Vascular Calcification
(blood, etiology)
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