Abstract | BACKGROUND: METHODS: RESULTS: After cerebral ischemic reperfusion, the rats showed neurobehavioral function deficit and cerebral infarction in the ischemic hemisphere. The number of apoptotic cells, the expressions and the concentrations in brain tissue of TLR4, NFkappaB and TNFalpha in ischemia control group increased significantly than those in the sham operative group (P < 0.01). Compared with the ischemia control group, the neurobehavioral scores, the infarction volumes, the apoptotic cells, the expressions and concentrations in brain tissue of TLR4, NFkappaB and TNFalpha were obviously decreased both in the picroside 2 and salvianic acid A sodium groups (P < 0.01). There was no statistical difference between the two treatment groups in above indexes (P > 0.05). CONCLUSIONS: Picroside 2 could down-regulate the expressions of TLR4, NFkappaB and TNFalpha to inhibit apoptosis and inflammation induced by cerebral ischemic reperfusion injury and improve the neurobehavioral function of rats.
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Authors | Yunliang Guo, Xinying Xu, Qin Li, Zhen Li, Fang Du |
Journal | Behavioral and brain functions : BBF
(Behav Brain Funct)
Vol. 6
Pg. 43
(Jul 09 2010)
ISSN: 1744-9081 [Electronic] England |
PMID | 20618938
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Caffeic Acids
- Cinnamates
- Glucosides
- Iridoid Glucosides
- Lactates
- NF-kappa B
- Tlr4 protein, rat
- Toll-Like Receptor 4
- Tumor Necrosis Factor-alpha
- picroside II
- salvianolic acid A
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Topics |
- Animals
- Anti-Inflammatory Agents
(chemistry, pharmacology)
- Apoptosis
(drug effects)
- Brain
(drug effects, metabolism, pathology)
- Brain Ischemia
(drug therapy, metabolism, pathology)
- Caffeic Acids
(chemistry, pharmacology)
- Cinnamates
(chemistry, pharmacology)
- Disease Models, Animal
- Encephalitis
(drug therapy, metabolism, pathology)
- Female
- Glucosides
(chemistry, pharmacology)
- Infarction, Middle Cerebral Artery
(drug therapy, metabolism, pathology)
- Iridoid Glucosides
- Lactates
(chemistry, pharmacology)
- NF-kappa B
(metabolism)
- Neuropsychological Tests
- Random Allocation
- Rats
- Rats, Wistar
- Reperfusion Injury
(drug therapy, metabolism, pathology)
- Toll-Like Receptor 4
(metabolism)
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(metabolism)
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