Abstract | BACKGROUND: It has been shown in experimental animal models that were extended to humans that during autoimmune conditions, the immune system generates beneficial autoantibody (auto Ab) response to a limited number of inflammatory mediators that drive the pathogenesis of the disease. OBJECTIVE: METHODS: RESULTS: Highly significant increased titers of auto Abs to TNF-alpha and IFN-alpha were detected in patients with psoriasis compared with healthy subjects and patients with AD (mean titers more than fourfold). These auto Abs demonstrated some neutralizing activity in vitro, but their serum levels did not correlate with the intensity and duration of the disease and with phototherapy induced remissions. Significantly increased titers albeit to a lesser extent, of auto Abs to CCL3 were detected in AD. CONCLUSIONS:
Psoriasis patients produce markedly increased levels of auto Abs to TNF-alpha and IFN-alpha which are two of the key cytokines in this disorder. The presence of these auto Abs which possess some neutralizing activity in vitro, may be an epiphenomenon or might play a role in attempting to suppress the ongoing inflammatory process.
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Authors | R Bergman, M Ramon, G Wildbaum, E Avitan-Hersh, E Mayer, A Shemer, N Karin |
Journal | Journal of dermatological science
(J Dermatol Sci)
Vol. 56
Issue 3
Pg. 163-7
(Dec 2009)
ISSN: 1873-569X [Electronic] Netherlands |
PMID | 19800767
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Chemokines
- Interferon-alpha
- Interleukin-17
- Tumor Necrosis Factor-alpha
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Topics |
- Adult
- Aged
- Autoantibodies
(blood)
- Autoimmunity
- Chemokines
(blood)
- Dermatitis, Atopic
(immunology)
- Female
- Humans
- Interferon-alpha
(immunology)
- Interleukin-17
(blood)
- Male
- Middle Aged
- Psoriasis
(immunology)
- Tumor Necrosis Factor-alpha
(immunology)
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