Abstract |
The neuroprotective effect of an ethyl acetate extract of Morinda citrifolia (Rubiaceae) Linn. fruits (EMC, ethyl acetate extract of Morinda citrifolia) at doses of 200 and 400 mg/kg, p.o. was studied on beta-amyloid (25-35) peptide induced cognitive dysfunction in mice. In the step-down inhibitory avoidance, EMC exhibited a significant increase in short-term memory and long-term memory (p < 0.05). A significant decrease (p < 0.01) in escape latency was noticed in the animals in the water maze. A significant increase (p < 0.01) in alteration of behavior was exhibited upon administration of EMC 200 and 400 mg/kg on the Y maze. Exploratory parameters such as line crossings, head dipping and rearing were increased significantly in EMC treated groups in a dose-dependent manner (p < 0.05 and p < 0.01). A significant reduction (p < 0.05) in acetyl cholinesterase activity was noticed in the EMC 200 and 400 mg/kg treated groups. The level of monoamine oxidase-A was decreased by the administration of EMC 200 and 400 mg/kg (p < 0.05 and p < 0.01, respectively). EMC at a dose of 400 mg/kg exhibited a significant increase (p < 0.01) in the levels of serotonin and dopamine. Antioxidant enzymes such as superoxide dismutase, glutathione reductase, glutathione peroxidase and ascorbic acid were decreased significantly in the b- amyloid peptide injected group, whose levels were restored significantly (p < 0.01) by the administration of EMC (400 mg/kg).
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Authors | P Muralidharan, V Ravi Kumar, G Balamurugan |
Journal | Phytotherapy research : PTR
(Phytother Res)
Vol. 24
Issue 2
Pg. 252-8
(Feb 2010)
ISSN: 1099-1573 [Electronic] England |
PMID | 19585480
(Publication Type: Journal Article)
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Copyright | (c) 2009 John Wiley & Sons, Ltd. |
Chemical References |
- Amyloid beta-Peptides
- Neuroprotective Agents
- Peptide Fragments
- Plant Extracts
- amyloid beta-protein (25-35)
- Serotonin
- Monoamine Oxidase
- Dopamine
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Topics |
- Amyloid beta-Peptides
- Animals
- Avoidance Learning
(drug effects)
- Cognition Disorders
(chemically induced, drug therapy)
- Dopamine
(analysis)
- Female
- Fruit
(chemistry)
- Male
- Maze Learning
(drug effects)
- Memory, Short-Term
(drug effects)
- Mice
- Mice, Inbred Strains
- Monoamine Oxidase
(analysis)
- Morinda
(chemistry)
- Motor Activity
(drug effects)
- Neuroprotective Agents
(pharmacology)
- Peptide Fragments
- Plant Extracts
(pharmacology)
- Serotonin
(analysis)
- Toxicity Tests, Acute
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