Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: KEY RESULTS: Rats showed grossly visible signs and symptoms of TAO on the 12th day after sodium laurate injection. In these rats, blood was in a hypercoagulable state; plasma urocortin, prostaglandin E(2) and soluble intercellular adhesion molecule-1 levels were elevated; and the expression of urocortin, CRF(1) and CRF(1alpha)-receptors, COX-2 and ICAM-1 in rat femoral arteries were markedly increased. Exogenous urocortin, given for 12 days after sodium laurate, exacerbated the hypercoagulable state and augmented expression of CRF(1alpha)-receptors, COX-2 and ICAM-1. These effects were abolished by a CRF(1)-receptor antagonist, NBI-27914, or a non-selective CRF-receptor antagonist, astressin, but not by the CRF(2)-receptor antagonist, antisauvagine-30, given with exogenous urocortin. CONCLUSION AND IMPLICATIONS:
|
Authors | Youhua Xu, Rongjian Zhang, Jie Chen, Qichun Zhang, Juejin Wang, Jue Hu, Xiaowei Guan, Lai Jin, Hong Fu, Bo Gui, Yuanyuan Guo, Shengnan Li |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 157
Issue 8
Pg. 1368-79
(Aug 2009)
ISSN: 1476-5381 [Electronic] England |
PMID | 19572944
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- 2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine
- Aniline Compounds
- Lauric Acids
- Peptide Fragments
- Pyrimidines
- Receptors, Corticotropin-Releasing Hormone
- Urocortins
- antisauvagine 30
- lauric acid
- Intercellular Adhesion Molecule-1
- astressin
- Thromboxane B2
- CRF receptor type 1
- Corticotropin-Releasing Hormone
- Cyclooxygenase 2
- Dinoprostone
|
Topics |
- Aniline Compounds
(pharmacology)
- Animals
- Arteritis
(blood, chemically induced, metabolism)
- Blood Coagulation
(drug effects)
- Corticotropin-Releasing Hormone
(antagonists & inhibitors, pharmacology)
- Cyclooxygenase 2
(biosynthesis)
- Dinoprostone
(blood)
- Intercellular Adhesion Molecule-1
(metabolism)
- Lauric Acids
- Male
- Peptide Fragments
(pharmacology)
- Pyrimidines
(pharmacology)
- Rats
- Rats, Wistar
- Receptors, Corticotropin-Releasing Hormone
(antagonists & inhibitors, biosynthesis)
- Thromboangiitis Obliterans
(blood, chemically induced, metabolism)
- Thromboxane B2
(blood)
- Urocortins
(blood, pharmacology, physiology)
|