Abstract | BACKGROUND: METHODS: In a cohort of 72 HD patients (36 (50%) had a positive HCV EIA test and 36 (50%) had a negative anti-HCV test), we examined HCV antibody status, insulin resistance (HOMA-IR) and beta-cell function (HOMA-beta), serum inflammatory parameters (high sensitive C-reactive protein (CRP), fibrinogen and procalcitonin), and performed echocardiography, high-resolution brachial artery ultrasound and B-mode carotid Doppler examination to assess the vascular functions and atherosclerosis. RESULTS: There were no differences in age, gender, body mass index (BMI), primary disease, duration of dialysis, smoking status, laboratory parameters except glucose, total cholesterol and LDL cholesterol between anti-HCV-positive and anti-HCV-negative groups. The serum concentrations of glucose, total cholesterol and LDL cholesterol were significantly lower in the anti-HCV-positive patients than anti-HCV-negative patients (p = 0.04, p = 0.02, p = 0.01, respectively). There were no significant differences in inflammatory parameters, total insulin secretion (HOMA-beta, p = 0.76) and insulin resistance (HOMA-R, p = 0.91) between anti-HCV-positive and negative patients. The intima media thickness, carotid plaque score and brachial artery endothelium-dependent dilatation did not differ significantly between the two groups (p = 0.44, 0.45, and 0.17, respectively). CONCLUSION:
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Authors | Y Caliskan, H Oflaz, H Pusuroglu, H Boz, H Yazici, S Tamer, K Karsidag, A Yildiz |
Journal | Clinical nephrology
(Clin Nephrol)
Vol. 71
Issue 2
Pg. 147-57
(Feb 2009)
ISSN: 0301-0430 [Print] Germany |
PMID | 19203507
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Atherosclerosis
(blood)
- Biomarkers
(blood)
- Chi-Square Distribution
- Female
- Hepatitis C
(blood)
- Humans
- Inflammation
(blood)
- Insulin Resistance
- Male
- Middle Aged
- Renal Dialysis
- Ultrasonography, Doppler
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