Procalcitonin

A peptide prohormone precursor of CALCITONIN. It is normally present at low levels in serum, but is released into the bloodstream, primarily from neuroendocrine cells in the lungs and intestines, in response to INFLAMMATION and BACTERIAL INFECTIONS. It is a diagnostic marker for BACTEREMIA.

Also Known As:

Networked: 6028 relevant articles (199 outcomes, 1098 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schuetz, Philipp: 91 articles (01/2022 - 08/2005)
2.	Mueller, Beat: 54 articles (01/2020 - 04/2004)
3.	Christ-Crain, Mirjam: 46 articles (01/2020 - 02/2004)
4.	Müller, Beat: 38 articles (01/2020 - 10/2002)
5.	Nobre, Vandack: 21 articles (01/2020 - 03/2008)
6.	Reinhart, Konrad: 19 articles (10/2021 - 01/2006)
7.	Stolz, Daiana: 19 articles (01/2020 - 01/2006)
8.	Gervaix, Alain: 19 articles (10/2017 - 04/2003)
9.	Tamm, Michael: 17 articles (01/2020 - 02/2004)
10.	Chastre, Jean: 16 articles (01/2020 - 01/2005)

Related Diseases

1.	Sepsis (Septicemia) 01/01/2023 - "PKM2 was an independent risk factor for sepsis and had the best diagnostic efficacy when combined with procalcitonin, with the AUC value of 0.9352. " 10/01/2018 - "[Procalcitonin as a  tool for the assessment of successful therapy of severe sepsis : An analysis using clinical routine data]." 10/01/2002 - "Amino-prohormone procalcitonin-reactive antiserum administration resulted in a significant improvement or a beneficial trend in a majority of the measured physiologic and metabolic derangements induced by sepsis. " 06/01/2017 - "This study comparatively evaluated the value of dynamic procalcitonin (PCT) and presepsin measurements in assessing therapeutic efficacy and prognosis for patients with severe sepsis. " 11/01/2007 - "Ultrasensitive assays for procalcitonin, capable of measuring low levels in healthy individuals, may help to identify even 'subclinical' inflammatory states before the development of clinically evident sepsis. "
2.	Infections 06/13/2009 - "In most infections a true gold standard for diagnosis does not exist, therefore physicians must remain sceptical towards observational studies evaluating procalcitonin. " 07/01/2012 - "Procalcitonin levels for intensive care unit transfers for probable or definite infection were 2.28 ng/mL [interquartile range 0.68-8.05], and were significantly greater than rapid response team visits that did not result in transfer (p = .0001). " 01/01/2022 - "Results were presented according to procalcitonin cut-off values, gold standard test used to confirm infection, and overall study conclusion(s), among other variables. " 02/01/2014 - "A procalcitonin ≥0.85 ng/ml might be helpful for early identifying CKD patients with infection." 10/01/2011 - "Procalcitonin might be the marker helpful in mold infection diagnosis."
3.	Bacterial Infections (Bacterial Infection) 07/01/2016 - "Procalcitonin (PCT) has shown promise in predicting the presence and degree of bacterial infections. " 03/10/2014 - "Procalcitonin (PCT) is helpful for diagnosing bacterial infections. " 04/13/2004 - "We hypothesized that serum procalcitonin, a marker of systemic bacterial infection, might be helpful in its diagnosis. " 05/30/2023 - "The BATCH trial will assess the effectiveness of an additional procalcitonin test in children (aged 72 h to 18 years) hospitalised with suspected or confirmed bacterial infection to guide antimicrobial prescribing decisions. " 05/30/2023 - "The BATCH trial is a multi-centre randomised controlled trial to compare procalcitonin-guided management of severe bacterial infection in children with current management. "
4.	Respiratory Tract Infections (Respiratory Tract Infection) 12/01/2021 - "Most clinical studies supporting procalcitonin (PCT)-guided management of lower respiratory tract infections have been performed in adults. " 01/01/2018 - "This meta-analysis of patient data from 26 randomised controlled trials was designed to assess safety of procalcitonin-guided treatment in patients with acute respiratory infections from different clinical settings. " 05/01/2011 - "Procalcitonin for triage of patients with respiratory tract symptoms: a case study in the trial design process for approval of a new diagnostic test for lower respiratory tract infections." 07/01/2007 - "There is no study on the value of procalcitonin measurements in adults with lower respiratory tract infection (LRTI) treated in primary care. " 01/01/2006 - "Sera obtained from children participating in a phase 3 PCV efficacy trial who were hospitalized for treatment of clinically diagnosed lower respiratory tract infection (C-LRTI) were retrospectively analyzed for CRP and procalcitonin measurements. "
5.	Fever (Fevers) 06/29/2021 - "This study aimed at evaluating the prognostic role of serum Procalcitonin (PCT) measurement among adult patients admitted to the ED with fever. " 04/06/2016 - "Higher diagnostic accuracy and cost-effectiveness using procalcitonin in the treatment of emergency medicine patients with fever (The HiTEMP study): a multicenter randomized study." 04/01/2012 - "The aim of the present study was to determine if blood procalcitonin can serve as an aid to differentiate between bacterial and nonbacterial cause of fever in children after cardiac surgery. " 01/13/2023 - "Univariate and multivariate analyses suggested that temperature at fever and procalcitonin were variables of significant difference between positive and negative blood culture patients. " 05/01/2022 - "We retrospectively analyzed the medical records of 1,052 patients (age ≥16 years) with fever (temperature ≥38°C) and serum procalcitonin levels of ≥2.0 ng/mL, and blood culture results. "

Related Drugs and Biologics

1.	C-Reactive Protein
2.	Biomarkers (Surrogate Marker)
3.	Anti-Bacterial Agents (Antibiotics)
4.	Interleukin-6 (Interleukin 6)
5.	Lactic Acid (Lactate)
6.	Proteins (Proteins, Gene)
7.	Serum Amyloid A Protein (Serum Amyloid A)
8.	Calcitonin (Calcitonin, Eel)
9.	Oxygen (Dioxygen)
10.	fibrin fragment D (D-dimer)

Related Therapies and Procedures

1.	Therapeutics
2.	Critical Care (Surgical Intensive Care)
3.	Length of Stay
4.	Duration of Therapy
5.	Continuous Renal Replacement Therapy