Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders.

Abstract

OBJECTIVE:

We determined the autoantibody profile in autoimmune thyroid diseases (AITD) and examined the distribution of thyroid-related autoantibodies in other autoimmune disorders.

METHODS:

We tested sera from 234 patients with Graves' disease (GD), 130 with Hashimoto's thyroiditis (HT), 249 with other autoimmune diseases, and 50 healthy controls by enzyme-linked immunosorbent assay or radioimmunoassay.

RESULTS:

Autoantibodies except TSH receptor antibody (Ab), anti-thyroglobulin (Tg) Ab and anti-thyroid peroxidase (TPO) Ab were not significantly prevalent in patients with AITD despite a significantly high elevation of thyroid-related Ab. Significant prevalence of autoantibodies related to AITD was observed in type 1 diabetes patients. Elevation of anti-Tg Ab was seen in patients with primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH), and anti-TPO Ab was elevated in patients with PBC. Although the prevalence of anti-acetylcholine receptor Ab and systemic lupus erythematosus (SLE)- related Ab was significant in AIH, primary Sjögren's syndrome (pSS)-related Ab were also found in both liver diseases. In myasthenia gravis (MG) patients, thyroid-related Ab and pSS-related Ab were detected in both MG groups, although SLE-related Ab were limited to the anti-muscle specific kinase Ab-positive MG patients. In patients with connective tissue diseases, anti- Tg Ab and anti-TPO Ab were significantly prevalent.

CONCLUSION:

Thyroid-related Ab were significantly elevated in all autoimmune diseases. Conversely, the elevations of Ab were not significant in the patients with AITD, suggesting a close relationship between AITD and other immune-mediated diseases.

• Authors: H Nakamura, T Usa, M Motomura, T Ichikawa, K Nakao, E Kawasaki, M Tanaka, K Ishikawa, K Eguchi
• Journal: Journal of endocrinological investigation (J Endocrinol Invest) Vol. 31 Issue 10 Pg. 861-5 (Oct 2008) ISSN: 1720-8386 [Electronic] Italy
• PMID: 19092289 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• Immunoglobulins, Thyroid-Stimulating
• thyrotropin-binding inhibitory immunoglobulin
• Thyroglobulin
• Iodide Peroxidase
• Glutamate Decarboxylase

Topics

• Adult
• Aged
• Arthritis, Rheumatoid (immunology)
• Autoantibodies (blood)
• Autoimmune Diseases (immunology)
• Diabetes Mellitus, Type 1 (immunology)
• Enzyme-Linked Immunosorbent Assay
• Female
• Glutamate Decarboxylase (immunology)
• Graves Disease (immunology)
• Hashimoto Disease (immunology)
• Hepatitis, Autoimmune (immunology)
• Humans
• Immunoglobulins, Thyroid-Stimulating (analysis)
• Iodide Peroxidase (immunology)
• Liver Cirrhosis, Biliary (immunology)
• Lupus Erythematosus, Systemic (immunology)
• Male
• Middle Aged
• Myasthenia Gravis (immunology)
• Prevalence
• Radioimmunoassay
• Sjogren's Syndrome (immunology)
• Thyroglobulin (immunology)
• Thyroid Diseases (epidemiology, immunology)