Abstract | OBJECTIVE: SETTING: Uludag University. DESIGN: Placebo-controlled animal study. ANIMALS: Adult mongrel dogs (n = 16). INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: Mean baseline plasma leptin and ghrelin levels were 2.4 +/- 0.1 ng/mL and 867 +/- 58 pg/mL, respectively. Plasma leptin and ghrelin increased significantly by 16% (p < .05) and 72% (p < .001) at 0.5 hr, and they remained elevated by 33-41% (p < .001) and 59-74% (p < .001) at 48 hrs after administration of endotoxin, respectively. There was positive correlation (r = .844; p < .001) between plasma leptin and ghrelin levels in endotoxin-treated dogs. Endotoxemia was associated with several-fold elevations in circulating levels of stress hormones, proinflammatory mediators, and hepatorenal injury markers. Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01). CONCLUSIONS:
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Authors | Zeki Yilmaz, Yesim Ozarda Ilcol, Ismail H Ulus |
Journal | Critical care medicine
(Crit Care Med)
Vol. 36
Issue 3
Pg. 828-33
(Mar 2008)
ISSN: 1530-0293 [Electronic] United States |
PMID | 18431270
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Dogs
- Endotoxemia
(blood)
- Female
- Ghrelin
(blood)
- Leptin
(blood)
- Male
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