Abstract | BACKGROUND: METHODS: RESULTS: Nine hundred ninety-one patients were enrolled with a 13.4% mortality rate. Despite no detectable difference in mortality among genders, estradiol was significantly elevated in nonsurvivors (16 pg/mL vs. 35 pg/mL, p < 0.001). Estradiol was a marker for injury severity with the most severely injured patients exhibiting the highest levels. The ability of estradiol to predict death (AUROC = 0.65) was comparable with Trauma and Injury Severity Score (AUROC = 0.65) and superior to Injury Severity Score (AUROC = 0.54) in this cohort. CONCLUSIONS: Serum estradiol is a marker of injury severity and a predictor of death in the critically injured patient, regardless of gender. Whether or not estradiol plays a causal role in outcomes is unclear, but estrogen modulation represents a potential therapy for improving outcomes in critically ill trauma patients.
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Authors | Lesly A Dossett, Brian R Swenson, Daithi Heffernan, Hugo Bonatti, Rosemarie Metzger, Robert G Sawyer, Addison K May |
Journal | The Journal of trauma
(J Trauma)
Vol. 64
Issue 3
Pg. 580-5
(Mar 2008)
ISSN: 1529-8809 [Electronic] United States |
PMID | 18332796
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
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Chemical References |
- Testosterone
- Progesterone
- Estradiol
- Prolactin
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Topics |
- APACHE
- Adult
- Area Under Curve
- Estradiol
(blood)
- Female
- Hospital Mortality
- Humans
- Injury Severity Score
- Logistic Models
- Male
- Middle Aged
- Predictive Value of Tests
- Progesterone
(blood)
- Prolactin
(blood)
- Prospective Studies
- ROC Curve
- Statistics, Nonparametric
- Testosterone
(blood)
- Wounds and Injuries
(blood, mortality)
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