Gastroprotective and antioxidant effects of montelukast on indomethacin-induced gastric ulcer in rats.

Abstract

Montelukast, a selective reversible cysteinyl leukotriene D(4)-receptor (LTD(4) receptor) antagonist, is used in the treatment of asthma. We have investigated alterations in the glutathione (GSH) and activity levels of antioxidative enzymes [superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), and glutathione reductase (GR)] and myeloperoxidase (MPO), as markers of the ulceration process following oral administration of montelukast, lansoprazole, famotidine, and ranitidine, respectively, in rats with indomethacin-induced ulcers. In the present study, we found that 1) montelukast, lansoprazole, famotidine, and ranitidine all reduced the development of indomethacin-induced gastric damage, with this reduction occurring at a greater magnitude for montelukast, famotidine, and lansoprazole than for ranitidine; 2) montelukast and ranitidine both alleviated increases in the activity levels of CAT and GST enzymes resulting from gastric injury; 3) montelukast and ranitidine both ameliorated depressions in the GSH and activity levels of SOD and GR enzymes caused by indomethacin administration; and 4) all doses of montelukast, lansoprazole, and ranitidine decreased amplification of MPO activity resulting from induced gastric injuries. These results suggest that the gastroprotective effects of montelukast on indomethacin-induced ulcerations can be attributed to its ameliorating effect on oxidative damage and MPO activity.

• Authors: Gunnur Ozbakis Dengiz, Fehmi Odabasoglu, Zekai Halici, Elif Cadirci, Halis Suleyman
• Journal: Journal of pharmacological sciences (J Pharmacol Sci) Vol. 105 Issue 1 Pg. 94-102 (Sep 2007) ISSN: 1347-8613 [Print] Japan
• PMID: 17895592 (Publication Type: Journal Article)

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Acetates
• Anti-Ulcer Agents
• Antioxidants
• Cyclopropanes
• Gastrointestinal Agents
• Histamine H2 Antagonists
• Quinolines
• Sulfides
• Lansoprazole
• Famotidine
• Ranitidine
• Catalase
• Peroxidase
• Superoxide Dismutase
• Glutathione Reductase
• Glutathione Transferase
• montelukast
• Indomethacin

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles (pharmacology, therapeutic use)
• Acetates (chemistry, pharmacology, therapeutic use)
• Animals
• Anti-Ulcer Agents (pharmacology, therapeutic use)
• Antioxidants (chemistry, pharmacology, therapeutic use)
• Catalase (metabolism)
• Cyclopropanes
• Dose-Response Relationship, Drug
• Famotidine (pharmacology, therapeutic use)
• Gastrointestinal Agents (chemistry, pharmacology, therapeutic use)
• Glutathione Reductase (metabolism)
• Glutathione Transferase (metabolism)
• Histamine H2 Antagonists (pharmacology, therapeutic use)
• Indomethacin (administration & dosage, toxicity)
• Intubation, Gastrointestinal
• Lansoprazole
• Male
• Molecular Structure
• Peroxidase (metabolism)
• Quinolines (chemistry, pharmacology, therapeutic use)
• Ranitidine (pharmacology, therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Stomach (drug effects, enzymology, pathology)
• Stomach Ulcer (chemically induced, prevention & control)
• Sulfides
• Superoxide Dismutase (metabolism)