Stomach Ulcer (Gastric Ulcer)

Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

Also Known As:

Networked: 5325 relevant articles (395 outcomes, 820 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Duodenal Ulcer (Curling's Ulcer)
2.	Ulcer
3.	Hemorrhage
4.	Stomach Ulcer (Gastric Ulcer)
5.	Peptic Ulcer (Peptic Ulcers)

Experts

1.	Brzozowski, T: 26 articles (10/2013 - 05/2000)
2.	Konturek, S J: 24 articles (08/2010 - 05/2000)
3.	Konturek, P C: 20 articles (08/2010 - 05/2000)
4.	Hiruma-Lima, Clélia Akiko: 16 articles (11/2015 - 04/2002)
5.	Vilegas, Wagner: 15 articles (11/2015 - 09/2002)
6.	Goel, R K: 15 articles (08/2009 - 04/2000)
7.	Palit, Gautam: 14 articles (06/2015 - 08/2004)
8.	Higuchi, Kazuhide: 13 articles (07/2015 - 07/2002)
9.	Arakawa, Tetsuo: 12 articles (05/2013 - 07/2002)
10.	Takeuchi, Koji: 12 articles (01/2013 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Stomach Ulcer:

1.	Ranitidine (Zantac)FDA LinkGeneric 06/10/1990 - "The results of this trial suggest that, in the treatment of gastric ulcers, the early-evening administration of ranitidine 300 mg is more effective than other modes of ingestion." 07/01/1993 - "Ranitidine 150 mg twice daily is effective for the treatment of gastric ulcers. " 07/01/1993 - "Ranitidine 300 mg at bedtime is effective for gastric ulcers: a 12-wk, multicenter, randomized, double-blind, placebo-controlled comparison. " 12/01/1989 - "The results suggest that ranitidine is effective in preventing gastric ulcer relapse." 07/01/1986 - "The results of this trial show that 300 mg of ranitidine administered at night is an effective and safe alternative to the current twice daily regimen for the short term treatment of gastric ulcer."
2.	Omeprazole (Esomeprazole)FDA LinkGeneric 04/01/1999 - "This study demonstrates that omeprazole paste, 4 mg/kg bwt per os, once daily, is highly effective in healing gastric ulcers in Thoroughbred racehorses and that either a full dose or half dose of omeprazole paste effectively prevents the recurrence of EGUS. " 07/01/2003 - "It was concluded that omeprazole paste at 4 mg/kg BW orally, once daily is highly effective in healing gastric ulcers in standardbred racehorses in training and that a dose of 2 mg/kg BW orally, once daily, effectively prevents the recurrence of gastric ulcers in most horses." 01/01/1992 - "The results indicate that omeprazole is highly effective for the treatment of refractory gastric ulcers." 04/01/1999 - "A multicentre, blinded, randomised complete-block, field trial was conducted with 140 horses and foals age 4 weeks-28 years to determine if omeprazole paste is effective and safe in promoting healing of spontaneous gastric ulcers under a variety of field conditions and in different breeds and ages of horses. " 04/01/1999 - "By Day 28, gastric ulcers were completely healed in 77% of omeprazole-treated horses, while 92% were significantly (P < 0.01) improved. "
3.	Cimetidine (Biomet)FDA LinkGeneric 01/01/1980 - "We studied the healing efficacy of cimetidine or placebo on 24 endoscopically proven prepyloric gastric ulcer outpatients in randomized controlled prospective double blind trial. " 03/01/2011 - "NS and NH are equally effective in healing of gastric ulcer similar to cimetidine. " 01/01/1984 - "It is concluded with caution that cimetidine might be effective in haemorrhage from gastric ulcer in patients 60 years and older. " 01/01/1988 - "The efficacy of a 4-week cimetidine treatment was examined by a double-blind randomized study in 37 outpatients with endoscopically verified chronic gastric ulcer. " 10/01/1983 - "The efficacy of Cimetidine in gastric ulcer, however requires further study."
4.	Ethanol (Ethyl Alcohol)IBA 03/01/2007 - "glandulosa (AG) showed a dose-dependent effect and significant reduction of gastric ulcers induced by absolute ethanol at the doses of 500 (57%) and 1000 mg/kg (85%) in relation to the control group. " 10/03/2005 - "Pharmacological experiments clearly demonstrated that the extracts of all plants given orally showed significant gastric protection against the ethanol-induced gastric ulcer model in rats. " 04/26/2005 - "The present work aimed at testing, in a rat model of ethanol-induced gastric ulceration, a local folk medicinal claim that dates are beneficial in gastric ulcers in humans. " 07/01/2012 - "A Comparison between Water and Ethanol Extracts of Rumex acetosa for Protective Effects on Gastric Ulcers in Mice." 01/01/2007 - "In summary, our results demonstrate that OSO pretreatment exerts protective effects in ethanol-induced gastric ulcers in rats. "
5.	Misoprostol (Cytotec)FDA LinkGeneric 01/01/1995 - "The efficacy of 400 micrograms misoprostol daily in the prevention of NSAID (non-steroidal anti-inflammatory drug)-induced gastric ulcer has been proven. " 11/11/1996 - "The use of misoprostol, but no that of H2 blockers, was beneficial in the prevention of NSAID-induced gastric ulcers. " 08/01/2004 - "Although misoprostol is slightly more effective in preventing gastric ulcers in these patients, PPIs are better tolerated. " 03/01/1990 - "Misoprostol has a disadvantageous safety profile relative to available agents but is effective in preventing NSAID-induced gastric ulcers. " 09/01/1989 - "Misoprostol has been shown to be an effective agent for the prevention of NSAID-induced gastric ulcers. "
6.	Sucralfate (Carafate)FDA LinkGeneric 03/01/1984 - "Controlled therapeutic trials have demonstrated that sucralfate 1g 4 times daily is effective in increasing the rate of healing of duodenal and gastric ulcer over a period of 4 to 8 weeks. " 08/08/1991 - "The results suggest that 2 g sucralfate twice daily is as effective in the healing of gastric ulcer as 1 g sucralfate q.i.d." 08/08/1991 - "Clinical efficacy of sucralfate in the treatment of gastric ulcer." 07/01/1990 - "Maintenance treatment with sucralfate delayed symptoms of gastric ulcer recurrence. " 01/01/2007 - "The purpose of the investigation was to study the effects of sucralfate on the biochemical composition as well as the anti-radicals and antioxidative activity (ARA; AOA) of the gastric supra-epithelial mucosal layer (GSEML) in patients with Helicobacter pylori (HP)-associated gastric ulcer (GU). "
7.	Famotidine (Pepcid)FDA LinkGeneric 01/01/1987 - "The findings show that the new H2-receptor antagonist famotidine, administered as a single evening dose, significantly speeds the healing of benign gastric ulcers and that it is a safe and highly effective treatment of gastric ulceration. " 10/24/1986 - "Analysis of data from 15 countries has shown that famotidine is more effective than placebo in treating gastric ulcers. " 04/01/1991 - "A multicentre, double-blind, randomized, placebo-controlled trial was undertaken to investigate the therapeutic efficacy of a nocturnal dose of famotidine 20 mg to reduce the 1 year relapse rate of recently healed gastric ulcers. " 10/01/1989 - "As shown in placebo-controlled trials, famotidine is effective in healing both duodenal and gastric ulcers. " 01/01/1992 - "Famotidine therefore proved effective in the treatment of gastric ulcer and was well tolerated on a short term basis."
8.	Indomethacin (Indometacin)FDA LinkGeneric 11/01/2005 - "racemosus was more effective in reducing gastric ulcer in indomethacin-treated gastric ulcerative rats, whereas W. " 08/01/2007 - "Trx-1 inhibits indomethacin-induced apoptotic signaling and gastric ulcer formation, suggesting that it may have a preventive and therapeutic potential against indomethacin-induced gastric injury." 07/01/2015 - "Therefore, this study aimed to investigate the protective effects of two natural extracts, namely ginger and marshmallow extracts, on indomethacin-induced gastric ulcer in rats. " 01/01/2015 - "This study investigated the protective effects of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats. " 05/01/2012 - "Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats."
9.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 03/01/2011 - "Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats." 07/01/2015 - "This study investigates the possible mechanism of the protective effect of ginger on aspirin induced gastric ulcer. " 07/01/2015 - "The postulated mechanism of the protective effect of ginger on the aspirin induced gastric ulcer: Histological and immunohistochemical studies." 09/01/2011 - "The aim of this study was to determine the antiulcer and antioxidant activities of Centaurium erythraea L (small centaury) in aspirin (ASA) induced acute gastric ulcer model. " 02/13/1995 - "This study suggests that the aspirin-induced gastric ulcer may not originate in the PVH but in the NTSm-DMX system."
10.	lansoprazole (Prevacid)FDA LinkGeneric 01/01/1995 - "The results of this study demonstrate that 30 mg lansoprazole once daily is remarkably effective in healing gastric ulcers because of its potent acid suppression. " 02/01/2015 - "In this study we aimed to compare the efficacy of a combination therapy with lansoprazole (LS) followed by ES with LS alone in treating endoscopic submucosal dissection (ESD)-induced iatrogenic gastric ulcers. " 01/01/2014 - "Comparison of the efficacy of 4- and 8-week lansoprazole treatment for ESD-induced gastric ulcers: a randomized, prospective, controlled study." 04/01/1998 - "Our purpose was to compare the safety and efficacy of lansoprazole 15 mg and 30 mg with placebo in preventing recurrence in 49 patients with a history of gastric ulcer. " 08/01/1995 - "A multicenter, double-blind study was conducted in 268 patients to compare the safety and efficacy of 15, 30, and 60 mg of lansoprazole and placebo in the treatment of gastric ulcer. "

Therapies and Procedures

1.	Ligation 07/21/2015 - "One hundred and twenty mice were randomly allocated into three types of gastric ulcer models (n = 40 each), induced by alcohol, restraint cold stress, or pyloric ligation. " 07/21/2015 - "butyricum) on experimental gastric ulcers (GUs) induced by alcohol, restraint cold stress, or pyloric ligation in mice, respectively. " 04/01/2014 - "To compare the anti-ulcerogenic activity of the above two drugs in pyloric ligation induced gastric ulcer in albino rats. " 07/01/2012 - "Different extracts [ethanolic, 50% hydroethanolic (50:50), 70% hydroethanolic (70:30) and aqueous] of young seedless pods were examined in pylorus ligation induced gastric ulcers in rats. " 08/01/2010 - "This protective ability of ELE against pylorus ligation-induced gastric ulcer could be attributed to its free radical scavenging and antioxidant properties. "
2.	Gastrectomy 10/01/1975 - "Of 61 patients with gastric ulcer subjected to an improved technique of segmental gastrectomy, 26 were available for follow-up study for 1 to 10 years; evaluations were made mainly on the postoperative reduction of gastric acid secretion and motor function of the gastric remnant. " 06/01/1967 - "Pylorus-preserving gastrectomy as an improved operation for gastric ulcer." 07/01/1936 - "A Case of Gastric Ulcer Cured by Gastrectomy After Forty-Five Years of Treatment." 01/01/2015 - "The results of imaging studies indicated a perforated gastric ulcer, and a distal gastrectomy was performed. " 07/01/2005 - "Our study was achieved on a group of 212 patients, clinically diagnosed with gastric ulcer and having partial gastrectomy. "
3.	Oral Administration 12/04/2015 - "Oral administration of HEMR (10mg/kg) reduced the gastric ulcer area by 53%, compared to the vehicle group (120.0±8.3mm(2)), the regeneration of gastric mucosa was evidenced in histological analysis. " 01/01/2015 - "Oral administration of LPZ-loaded nanoparticles healed 92.6%-95.7% of gastric ulcers in Wistar rats within 7 days. " 01/01/2015 - "The effect of oral administration of a PPI for 1 week on ESD-induced gastric ulcers has not yet been evaluated. " 09/01/2013 - "Sprague-Dawley rats (200-250 g) were given SEL, GSE, and both by oral gavage for 28 days, and then gastric ulcers were induced by oral administration of 25 mg/kg IND. " 05/01/2009 - "Gastrointestinal deposition of nanoparticles was examined after oral administration to mice suffering from an experimental gastric ulcer model. "
4.	Traditional Medicine (Folk Remedies) 01/30/2013 - "The main goals of this study were to establish the potential acute toxicity and the gastroprotective activity of aqueous extracts and compounds from Hintonia latiflora and Hintonia standleyana in order to demonstrate their preclinical efficacy for the treatment of gastric ulcers in Mexican folk medicine. " 01/01/2012 - "Hyptis suaveolens is a medicinal plant that is, according to traditional medicine, considered useful in the treatment of gastric ulcers. " 01/01/2011 - "Tithonia diversifolia is a medicinal plant from the Municipality of Suchiapa, Chiapas, Mexico, that according to local folk medicine is considered useful in the treatment of gastric ulcers. " 10/28/2013 - "This study corroborates the folk medicine use of Cenostigma macrophyllum for treatment of gastric ulcers, as well as reinforces this species as a valuable source of promising natural drugs with gastroprotective activity." 12/04/2015 - "Maytenus robusta Reissek (Celastraceae) is traditionally used in Brazilian folk medicine to treat gastric ulcer, as a substitute for M. "
5.	Endoscopic Hemostasis 07/01/2001 - "Endoscopic hemostasis for hemorrhagic gastric ulcer is effective and safe, even for such elderly patients." 02/01/2009 - "Gastrointestinal: Aneurysmal artery in a gastric ulcer after endoscopic hemostasis." 03/01/2004 - "We concluded that endoscopic hemostasis using high-frequency hemostatic forceps for hemorrhagic gastric ulcer is safe and effective method." 03/01/2004 - "[Endoscopic hemostasis using high-frequency hemostatic forceps for hemorrhagic gastric ulcer]." 12/01/2011 - "In spite of endoscopic hemostasis and medication, re-bleeding from the gastric ulcer occurred. "