Olfactory neuroblastoma. Additional immunohistochemical characterization.

Abstract

A panel of 12 antibodies was used to further characterize the immunohistochemical staining profile of olfactory neuroblastoma. The following results were obtained for the 11 neoplasms that were immunostained: neuron-specific enolase 11/11(+), S-100 protein 8/11(+), microtubule-associated protein-2 8/11(+), class III beta-tubulin isotype 9/11(+), neurofilament 200 kD 8/11(+), synaptophysin 7/11(+), glial fibrillary acidic protein 1/11(+), chromogranin A 1/11(+), vimentin 1/11(+), keratin (CAM 5.2) 4/11(+), keratin (AEI/AE3) 0/11(+), and epithelial membrane antigen 0/11(+). Expression of two intermediate filaments was found in 4 of the 11 tumors. The authors' data showing that 72% of olfactory neuroblastomas were S-100 protein positive and only one was immunoreactive for glial fibrillary acidic protein agree with other published immunohistochemical studies. With only a single exception, each of the 11 neoplasms was labeled with one or more antibodies that detect neuronal cytoskeletal proteins (class III beta-tubulin isotype, microtubule-associated protein-2, neurofilament 200 kD). These immunohistochemical results are complementary to the reported electron microscopic findings of intermediate filaments and microtubules in olfactory neuroblastomas.

• Authors: H F Frierson Jr, G W Ross, S E Mills, A Frankfurter
• Journal: American journal of clinical pathology (Am J Clin Pathol) Vol. 94 Issue 5 Pg. 547-53 (Nov 1990) ISSN: 0002-9173 [Print] England
• PMID: 1700595 (Publication Type: Journal Article)

Chemical References

• Chromogranin A
• Chromogranins
• Glial Fibrillary Acidic Protein
• Membrane Glycoproteins
• Membrane Proteins
• Microtubule-Associated Proteins
• Mucin-1
• S100 Proteins
• Synaptophysin
• Tubulin
• Vimentin
• Keratins
• Phosphopyruvate Hydratase

Topics

• Adult
• Aged
• Chromogranin A
• Chromogranins (metabolism)
• Female
• Glial Fibrillary Acidic Protein (metabolism)
• Humans
• Immunohistochemistry
• Keratins (metabolism)
• Male
• Membrane Glycoproteins (metabolism)
• Membrane Proteins (metabolism)
• Microtubule-Associated Proteins (metabolism)
• Middle Aged
• Mucin-1
• Nasopharyngeal Neoplasms (metabolism, pathology)
• Neuroectodermal Tumors, Primitive, Peripheral (metabolism, pathology)
• Phosphopyruvate Hydratase (metabolism)
• S100 Proteins (metabolism)
• Synaptophysin
• Tubulin (metabolism)
• Vimentin (metabolism)