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Mucin-1 (CA 15-3 Antigen)

Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.

Also Known As:

CA 15-3 Antigen; Epithelial Membrane Antigen; Antigens, CD227; CA 15.3 Antigen; CD227 Antigen; Antigen CA 15 3; Antigen, CA 15-3; Antigen, CA 15.3; Antigen, CA-15-3; Antigen, CD227; Antigen, Epithelial Membrane; CA 15 3 Antigen; CA-15-3, Antigen; CD227 Antigens; Membrane Antigen, Epithelial; Mucin 1; Mucin, Muc1; Mucin, Polymorphic Epithelial; Antigen CA-15-3; CA-15-3 Antigen; Episialin; Epithelial Mucin, Polymorphic; Muc1 Mucin; Polymorphic Epithelial Mucin

Networked: 2340 relevant articles (22 outcomes, 197 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Kufe, Donald: 20 articles (07/2015 - 05/2002)
2.	Gendler, Sandra J: 14 articles (06/2015 - 01/2003)
3.	Terada, Tadashi: 14 articles (05/2014 - 11/2003)
4.	Mukherjee, Pinku: 10 articles (08/2015 - 01/2003)
5.	Jeschke, Udo: 10 articles (01/2015 - 07/2007)
6.	Fletcher, Christopher D M: 10 articles (01/2014 - 01/2002)
7.	Fisher, Cyril: 9 articles (01/2016 - 02/2003)
8.	Kharbanda, Surender: 9 articles (01/2015 - 09/2003)
9.	Ahmad, Rehan: 9 articles (10/2013 - 06/2009)
10.	Mayr, Doris: 8 articles (01/2015 - 07/2007)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2006 - "Transduction with a fiber-modified adenoviral vector is superior to non-viral nucleofection for expressing tumor-associated Ag mucin-1 in human DC." 12/01/2014 - "Although studies regarding CA 19-9 exist, sufficient data on cancer antigen (CA) 15-3 are not available. " 04/01/2014 - "The obtained cells are used as an applicable model of MUC1-expressing cancers and might be used to study the role of different functional fragments of mucin MUC1 in metastasizing. " 07/01/2013 - "Immunohistochemical study showed that the tumor cells in all cases were strongly positive for AE1/AE3, epithelial membrane antigen, CK7 and CK18. " 11/01/2012 - "DF3/MUC1 mucin is expressed in various cancer tissues, and many in vitro studies have suggested that it may play a role in the aggressive behavior of malignant tumors. "
2.	Carcinoma (Carcinomatosis) 08/01/2001 - "To investigate the efficacy of discovery of cervical lymph nodes micrometastasis of supraglottic carcinomas by detection of mucin (MUC1) gene. " 01/01/2015 - "Recent studies have highlighted the overexpression of mucin 1 (MUC1) in various epithelial carcinomas and its role in tumorigenesis. " 01/01/2012 - "Another aim of this study was to evaluate Mucin-1 expression by immunohistochemistry in a different cohort of ovarian carcinoma patients with respect to grade, stage and survival. " 02/16/2005 - "To study the relationship of abnormal expression of mucin 1 with the invasiveness of breast carcinoma cells. " 10/01/2003 - "This study indicates that osteoid formation and negative expression of epithelial membrane antigen are key features in the differentiation from metastatic carcinoma."
3.	Adenocarcinoma 12/01/2010 - "Since epithelial mucin 1 (MUC1) is associated with several adenocarcinomas at the mucosal sites, it is pertinent to test the efficacy of a mucosally targeted vaccine formulation. " 01/01/2014 - "A previous successful phase 1 trial was conducted in patients with adenocarcinoma who were injected with Cvac, autologous monocyte-derived dendritic cells (DCs) incubated with mannosylated mucin 1 protein (M-FP). " 05/01/1998 - "Clinical diagnosis of adenocarcinoma was suspected but the pathological study showed an anaplastic morphology, with little plasmacytic differentiation and lack of stain with cytokeratins and epithelial membrane antigen (EMA), immunohistochemical marker of plasmatic cells, among others. " 05/01/2006 - "Human polymorphic epithelial mucin (MUC1) is a heavily glycosylated large protein that is frequently overexpressed on the surface of many human adenocarcinomas. " 11/01/2002 - "Membrane-associated mucin MUC1 is expressed in various adenocarcinoma cells and active T lymphocytes. "
4.	Mesothelioma 12/01/2014 - "The purpose of this study is to evaluate the utility of IMP3, GLUT-1, and epithelial membrane antigen (EMA) immunohistochemistry for distinguishing mesotheliomas from benign mesothelial proliferations. " 06/01/1988 - "For the differentiation between reactive mesothelial cells and malignant mesothelioma human milk fat globule and/or epithelial membrane antigen, in this study proved to be most reliable, their presence strongly indicating malignancy. " 03/01/2005 - "The value of epithelial membrane antigen expression in separating benign mesothelial proliferation from malignant mesothelioma: a comparative study." 02/25/2003 - "The detection of long microvilli, an ultrastructural feature unique for malignant epithelial mesothelioma, requires immunolabeling of epithelial membrane antigen to be visible by light microscopy. " 05/01/1992 - "Corresponding microvilli can be visualized by immunostaining for epithelial membrane antigen in both cell block preparations from effusions and biopsy specimens, allowing the identification of malignant mesothelioma. "
5.	Breast Neoplasms (Breast Cancer) 11/01/2014 - "Immunohistochemical studies proved that the presence of breast cancer (BrCa) is accompanied by elevated levels of epithelial membrane antigen (EMA) and decreased levels of cytokeratin-1 (CK1). " 01/01/2002 - "In the present study, we have investigated if the factors affecting cells proliferation could influence MUC1 mucin biosynthesis and shedding from cell surface into the culture medium in two human breast cancer cell lines: MCF-7 (ER+) and MDA-MB-231 (ER-). " 10/01/1997 - "To investigate the existence of such a gene dosage effect in breast cancer, we chose to study the MUC1 mucin gene located at 1q21-q24. " 10/01/2015 - "We previously found that the breast cancer cell line YMBS secretes mucin 1 possessing 3'-sulfated core1 (3Score1-MUC1) into the medium. " 10/01/2015 - "Expression of mucin 1 possessing a 3'-sulfated core1 in recurrent and metastatic breast cancer."

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5.	S100 Proteins (S 100 Protein)
6.	Antibodies
7.	Glial Fibrillary Acidic Protein
8.	Paraffin
9.	Epidermal Growth Factor (EGF)
10.	Epidermal Growth Factor Receptor (EGF Receptor)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Immunotherapy
3.	Heterologous Transplantation (Xenotransplantation)
4.	Radiotherapy
5.	Esophagectomy