Abstract | BACKGROUND: METHODS: RESULTS: GST enzyme activity, and levels of GST alpha, glutathione and cysteine in the pouch were significantly lower than those in the afferent loop (308 versus 398 nmol per min per mg protein (P<0.001), 4604 versus 5286 ng per mg protein (P=0.010), 27.1 versus 34.8 nmol per mg protein (P=0.023) and 0 versus 4.8 nmol per mg protein (P=0.009) respectively). No correlation was found between inflammation or colonic metaplasia of the pouch and GST enzyme activity in the pouch. CONCLUSION: After IPAA, GST detoxification activity in the pouch is significantly lower than that in the afferent ileal loop, which may promote tumorigenesis.
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Authors | P Friederich, M Berkhout, H M J Roelofs, H van Goor, J H J M van Krieken, W H M Peters, F M Nagengast |
Journal | The British journal of surgery
(Br J Surg)
Vol. 93
Issue 9
Pg. 1108-14
(Sep 2006)
ISSN: 0007-1323 [Print] England |
PMID | 16804871
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2006 British Journal of Surgery Society Ltd. |
Chemical References |
- Glutathione Transferase
- Glutathione
- Cysteine
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Topics |
- Adenomatous Polyposis Coli
(enzymology, pathology, surgery)
- Adolescent
- Adult
- Aged
- Biopsy, Needle
(methods)
- Colectomy
(methods)
- Colon
(enzymology, pathology)
- Colonic Pouches
(pathology)
- Cysteine
(metabolism)
- Female
- Glutathione
(metabolism)
- Glutathione Transferase
(metabolism)
- Humans
- Male
- Metaplasia
(enzymology, pathology)
- Middle Aged
- Proctocolectomy, Restorative
(adverse effects)
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